The role of leiomodin in actin dynamics: a new road or a secret gate.
actin
leiomodin
sarcomeres
tropomodulin
tropomyosin
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
10
05
2021
received:
15
03
2021
accepted:
16
07
2021
pubmed:
18
7
2021
medline:
20
10
2022
entrez:
17
7
2021
Statut:
ppublish
Résumé
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a significant part in understanding the functional significance of leiomodin's interacting partners and functional domains. In this review, we present the current state of knowledge on the structural and cellular properties of leiomodin which has led to two proposed mechanisms of its function. Although it is known that leiomodin is essential for life, numerous domains within leiomodin remain unstudied and as such, we outline future directions for investigations that we predict will provide evidence that leiomodin is a multifunctional protein.
Identifiants
pubmed: 34273242
doi: 10.1111/febs.16128
pmc: PMC8761783
mid: NIHMS1725705
doi:
Substances chimiques
Actins
0
Tropomodulin
0
Tropomyosin
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6119-6131Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM120137
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123078
Pays : United States
Informations de copyright
© 2021 Federation of European Biochemical Societies.
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