The use of tocofersolan as a rescue agent in larval zebrafish exposed to benzo[a]pyrene in early development.
Benzo[a]pyrene
Locomotion
Tocofersolan
Vitamin E
Zebrafish
Journal
Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
19
04
2021
revised:
25
06
2021
accepted:
12
07
2021
pubmed:
18
7
2021
medline:
5
2
2022
entrez:
17
7
2021
Statut:
ppublish
Résumé
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants created by incomplete combustion. Benzo(a)pyrene (BaP), the prototypic PAH, is known to exert toxicity through oxidative stress which is thought to occur through inhibition of antioxidant scavenging systems. The use of agents that reduce oxidative stress may be a valuable route for ameliorating the adverse effects of PAHs on neural development and behavior. This study was conducted to determine if tocofersolan (a synthetic water-soluble analog of vitamin E) supplementation can prevent or reduce neurobehavioral deficits in zebrafish embryos exposed to BaP during early development. Newly hatched zebrafish were assessed on locomotor activity and light responsivity. Zebrafish embryos were exposed to vehicle (DMSO), tocofersolan (0.3 μM-3 μM), and/or BaP (5 μM) from 5-120 hours post-fertilization. This concentration range was below the threshold for producing overt dysmorphogenesis or decreased survival. One day after the end of exposure the larval fish were tested for locomotor activity under alternating light and dark 10 min periods, BaP (5 μM) was found to cause locomotor hypoactivity in larval fish. Co-exposure of tocofersolan (1 μM) restored control-like locomotor function. Based on the findings of this study, this model can be expanded to assess the outcome of vitamin E supplementation on other potential environmental neurotoxicants, and lead to determination if this rescue persists into adulthood.
Identifiants
pubmed: 34273383
pii: S0161-813X(21)00081-4
doi: 10.1016/j.neuro.2021.07.003
pmc: PMC8440378
mid: NIHMS1726138
pii:
doi:
Substances chimiques
Water Pollutants, Chemical
0
Vitamin E
1406-18-4
Benzo(a)pyrene
3417WMA06D
tocophersolan
O03S90U1F2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-84Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES010356
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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