Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature.
Children
Infection
Panton-valentine leukocidin
Staphylococcus aureus
Journal
Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759
Informations de publication
Date de publication:
17 Jul 2021
17 Jul 2021
Historique:
received:
02
02
2021
accepted:
08
06
2021
entrez:
18
7
2021
pubmed:
19
7
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome. This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery. Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.
Sections du résumé
BACKGROUND
BACKGROUND
Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome.
CASE PRESENTATION
METHODS
This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery.
CONCLUSION
CONCLUSIONS
Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.
Identifiants
pubmed: 34274022
doi: 10.1186/s13052-021-01105-5
pii: 10.1186/s13052-021-01105-5
pmc: PMC8285845
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Toxins
0
Exotoxins
0
Leukocidins
0
Panton-Valentine leukocidin
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158Subventions
Organisme : Ministry of Health
ID : Ricerca Corrente 2021 438/03
Informations de copyright
© 2021. The Author(s).
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