Recent advances in drug repurposing using machine learning.
Alzheimer Disease
/ drug therapy
Antineoplastic Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Clemastine
/ pharmacology
Computational Biology
/ methods
Dipyridamole
/ pharmacology
Drug Repositioning
/ trends
Humans
Hydroxychloroquine
/ pharmacology
Lenalidomide
/ pharmacology
Machine Learning
Neoplasms
/ drug therapy
Neuroprotective Agents
/ therapeutic use
Piperazines
/ pharmacology
Piperidines
/ pharmacology
Protein Kinase Inhibitors
/ pharmacology
COVID-19 Drug Treatment
Drug discovery
Drug repurposing
Machine learning
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
11
05
2021
revised:
28
05
2021
accepted:
01
06
2021
pubmed:
19
7
2021
medline:
25
12
2021
entrez:
18
7
2021
Statut:
ppublish
Résumé
Drug repurposing aims to find new uses for already existing and approved drugs. We now provide a brief overview of recent developments in drug repurposing using machine learning alongside other computational approaches for comparison. We also highlight several applications for cancer using kinase inhibitors, Alzheimer's disease as well as COVID-19.
Identifiants
pubmed: 34274565
pii: S1367-5931(21)00081-8
doi: 10.1016/j.cbpa.2021.06.001
pmc: PMC8671152
mid: NIHMS1716900
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Antiviral Agents
0
Neuroprotective Agents
0
PB28 compound
0
Piperazines
0
Piperidines
0
Protein Kinase Inhibitors
0
Hydroxychloroquine
4QWG6N8QKH
Dipyridamole
64ALC7F90C
cloperastine
69M5L7BXEK
Clemastine
95QN29S1ID
Lenalidomide
F0P408N6V4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-84Subventions
Organisme : NIGMS NIH HHS
ID : R41 GM131433
Pays : United States
Organisme : NCCIH NIH HHS
ID : R43 AT010585
Pays : United States
Organisme : NIEHS NIH HHS
ID : R43 ES031038
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM122196
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: SE is the owner and FU and ACP are employees of Collaborations Pharmaceuticals, Inc.
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