Graph theoretical structural connectome analysis of the brain in patients with chronic spinal cord injury: preliminary investigation.
Journal
Spinal cord series and cases
ISSN: 2058-6124
Titre abrégé: Spinal Cord Ser Cases
Pays: England
ID NLM: 101680856
Informations de publication
Date de publication:
17 07 2021
17 07 2021
Historique:
received:
23
11
2020
accepted:
28
06
2021
revised:
25
06
2021
entrez:
18
7
2021
pubmed:
19
7
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Retrospective study. We aimed to characterize the convergent disruptions of the structural connectivity based on network modeling technique (i.e., graph theory) to identify significant changes in network organization/reorganization between uninjured and chronic spinal cord injury (SCI) participants. USA. Ten adult participants including 4 with chronic SCI and 6 uninjured were scanned using a multi-shell diffusion imaging on a 3.0 T MR scanner. Whole brain structural connectivity matrix was estimated by performing the quantification of the number of white matter fibers (called edges) connecting each possible pair of brain region (called nodes). Brain regions were defined according to Desikan-Killiany cortical atlas. Using connectivity matrix, connectivity strength as well as six different graph theoretical measurements were computed for each participant. They include: (1) global efficiency; (2) local efficiency; (3) degree; (4) betweenness centrality; (5) average shortest length and (6) clustering coefficient. Finally network based statistics was applied to extract nodes/connections with significant differences between groups (uninjured vs SCI). The SCI group showed significant decreases in betweenness centrality in the left precentral gyrus (T-score=2.98, p value=0.02), and the right caudal middle frontal gyrus (score = 2.35, p value=0.047). It also showed significant decrease in left transverse temporal gyrus (T-score=2.36, p value=0.046) in clustering coefficient. In addition, altered regions in the occipital and parietal lobe were also identified. These results suggest that not only local but also global alterations of the white matter occur after SCI. The proposed modeling technique has the potential to serve as a screening tool to identify any areas of the brain affected after SCI.
Identifiants
pubmed: 34274953
doi: 10.1038/s41394-021-00424-3
pii: 10.1038/s41394-021-00424-3
pmc: PMC8286254
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
60Subventions
Organisme : NINDS NIH HHS
ID : R01 NS097880
Pays : United States
Organisme : U.S. Department of Defense (DOD)
ID : W81XWH-17-1-0476
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : NS097880 (MRD)
Informations de copyright
© 2021. The Author(s), under exclusive licence to International Spinal Cord Society.
Références
J Neurotrauma. 2017 Mar 15;34(6):1156-1163
pubmed: 27717295
Brain Connect. 2017 Sep;7(7):413-423
pubmed: 28657334
J Spinal Cord Med. 2020 Jan;43(1):88-97
pubmed: 30508409
J Int Neuropsychol Soc. 1997 Sep;3(5):464-72
pubmed: 9322406
Brain Res. 2013 Apr 4;1504:58-73
pubmed: 23396112
PLoS Comput Biol. 2020 Apr 24;16(4):e1007514
pubmed: 32330126
Brain. 2006 Mar;129(Pt 3):718-28
pubmed: 16330503
Brain Struct Funct. 2018 Jun;223(5):2269-2285
pubmed: 29464318
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Neurology. 1998 Apr;50(4):1115-21
pubmed: 9566404
Neuroimage Clin. 2017 Nov 10;17:518-529
pubmed: 29201640
J Spinal Cord Med. 2013 Mar;36(2):74-81
pubmed: 23809520
Brain. 2014 Jan;137(Pt 1):12-32
pubmed: 23869106
J Neurosci. 2009 Sep 30;29(39):12210-9
pubmed: 19793979
Hum Brain Mapp. 2007 Dec;28(12):1334-46
pubmed: 17315225
Cereb Cortex. 2009 Jan;19(1):224-32
pubmed: 18483004
Arch Phys Med Rehabil. 1986 Feb;67(2):115-7
pubmed: 3954560
Ann Rehabil Med. 2015 Jun;39(3):374-83
pubmed: 26161343
J Neurotrauma. 2017 Mar 15;34(6):1278-1282
pubmed: 27937140
J Neurophysiol. 1996 May;75(5):2144-9
pubmed: 8734610
Front Psychol. 2014 Dec 16;5:1489
pubmed: 25566158
Front Hum Neurosci. 2015 Jun 30;9:386
pubmed: 26175682
Nat Rev Neurosci. 2001 Apr;2(4):263-73
pubmed: 11283749
Clin Neurophysiol. 2014 Jul;125(7):1295-305
pubmed: 24831083
Front Hum Neurosci. 2017 Oct 25;11:517
pubmed: 29163098
J Neurotrauma. 2018 Mar 15;35(6):864-873
pubmed: 29179629
Curr Opin Neurol. 2010 Aug;23(4):341-50
pubmed: 20581686
Front Neurosci. 2019 Jun 06;13:585
pubmed: 31249501
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
J Neurotrauma. 2009 Nov;26(11):2113-26
pubmed: 19604097
Neurosci Lett. 2001 Apr 27;303(1):62-6
pubmed: 11297824
Curr Pharm Des. 2005;11(11):1441-50
pubmed: 15853674
Brain Res Bull. 2018 Mar;137:107-119
pubmed: 29175055