Assessment of catabolic state in infants with the use of urinary titin N-fragment.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
24
02
2021
accepted:
02
07
2021
revised:
30
06
2021
pubmed:
19
7
2021
medline:
14
7
2022
entrez:
18
7
2021
Statut:
ppublish
Résumé
Urinary titin N-fragment levels have been used to assess the catabolic state, and we used this biomarker to evaluate the catabolic state of infants. We retrospectively measured urinary titin N-fragment levels of urinary samples. The primary outcome was its changes according to postmenstrual age. The secondary outcomes included differences between gestational age, longitudinal change after birth, influence on growth, and relationship with blood tests. This study included 219 patients with 414 measurements. Urinary titin N-fragment exponentially declined with postmenstrual age. These values were 12.5 (7.1-19.6), 8.1 (5.1-13.0), 12.8 (6.0-21.3), 26.4 (16.4-52.0), and 81.9 (63.3-106.4) pmol/mg creatinine in full, late, moderate, very, and extremely preterm infants, respectively (p < 0.01). After birth, urinary levels of titin N-fragment exponentially declined, and the maximum level within a week was associated with the time to return to birth weight in preterm infants (ρ = 0.39, p < 0.01). This was correlated with creatine kinase in full-term infants (ρ = 0.58, p < 0.01) and with blood urea nitrogen in preterm infants (ρ = 0.50, p < 0.01). The catabolic state was increased during the early course of the postmenstrual age and early preterm infants. Catabolic state in infants, especially in preterm infants, was expected to be increased, but no study has clearly verified this. In this retrospective study of 219 patients with 414 urinary titin measurements, the catabolic state was exponentially elevated during the early postmenstrual age. The use of the urinary titin N-fragment clarified catabolic state was prominently increased in very and extremely preterm infants.
Sections du résumé
BACKGROUND
Urinary titin N-fragment levels have been used to assess the catabolic state, and we used this biomarker to evaluate the catabolic state of infants.
METHODS
We retrospectively measured urinary titin N-fragment levels of urinary samples. The primary outcome was its changes according to postmenstrual age. The secondary outcomes included differences between gestational age, longitudinal change after birth, influence on growth, and relationship with blood tests.
RESULTS
This study included 219 patients with 414 measurements. Urinary titin N-fragment exponentially declined with postmenstrual age. These values were 12.5 (7.1-19.6), 8.1 (5.1-13.0), 12.8 (6.0-21.3), 26.4 (16.4-52.0), and 81.9 (63.3-106.4) pmol/mg creatinine in full, late, moderate, very, and extremely preterm infants, respectively (p < 0.01). After birth, urinary levels of titin N-fragment exponentially declined, and the maximum level within a week was associated with the time to return to birth weight in preterm infants (ρ = 0.39, p < 0.01). This was correlated with creatine kinase in full-term infants (ρ = 0.58, p < 0.01) and with blood urea nitrogen in preterm infants (ρ = 0.50, p < 0.01).
CONCLUSIONS
The catabolic state was increased during the early course of the postmenstrual age and early preterm infants.
IMPACT
Catabolic state in infants, especially in preterm infants, was expected to be increased, but no study has clearly verified this. In this retrospective study of 219 patients with 414 urinary titin measurements, the catabolic state was exponentially elevated during the early postmenstrual age. The use of the urinary titin N-fragment clarified catabolic state was prominently increased in very and extremely preterm infants.
Identifiants
pubmed: 34274960
doi: 10.1038/s41390-021-01658-5
pii: 10.1038/s41390-021-01658-5
doi:
Substances chimiques
Connectin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1748-1753Informations de copyright
© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
Références
Hug, L., Alexander, M., You, D. & Alkema, L. National, regional, and global levels and trends in neonatal mortality between 1990 and 2017, with scenario-based projections to 2030: a systematic analysis. Lancet Glob. Health 7, e710–e720 (2019).
pubmed: 31097275
pmcid: 6527519
doi: 10.1016/S2214-109X(19)30163-9
Patel, R. M. et al. Causes and timing of death in extremely premature infants from 2000 through 2011. N. Engl. J. Med. 372, 331–340 (2015).
pubmed: 25607427
pmcid: 4349362
doi: 10.1056/NEJMoa1403489
Pierrat, V. et al. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study. BMJ 358, j3448 (2017).
pubmed: 28814566
pmcid: 5558213
doi: 10.1136/bmj.j3448
Ancel, P.-Y. & Goffinet, F. Group at E-W survival and morbidity of preterm children born at 22 through 34 weeks’ gestation in France in 2011: results of the EPIPAGE-2 cohort study. JAMA Pediatr. 169, 230–238 (2015).
pubmed: 25621457
doi: 10.1001/jamapediatrics.2014.3351
Marlow, N., Wolke, D., Bracewell, M. A. & Samara, M. Neurologic and developmental disability at six years of age after extremely preterm birth. N. Engl. J. Med. 352, 9–19 (2005).
pubmed: 15635108
doi: 10.1056/NEJMoa041367
Clark, R. H., Thomas, P. & Peabody, J. Extrauterine growth restriction remains a serious problem in prematurely born neonates. Pediatrics 111, 986–990 (2003).
pubmed: 12728076
doi: 10.1542/peds.111.5.986
Fuchs, F. et al. Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS ONE 13, e0191002 (2018).
pubmed: 29385154
pmcid: 5791955
doi: 10.1371/journal.pone.0191002
Vogel, J. P. et al. The global epidemiology of preterm birth. Best Pr. Res. Clin. Obstet. Gynaecol. 52, 3–12 (2018).
doi: 10.1016/j.bpobgyn.2018.04.003
McCormick, M. C. & Litt, J. S. The outcomes of very preterm infants: is it time to ask different questions? Pediatrics 139, e20161694 (2017).
Pencharz, P. B., Masson, M., Desgranges, F. & Papageorgiou, A. Total-body protein turnover in human premature neonates: Effects of birth weight, intra-uterine nutritional status and diet. Clin. Sci. 61, 207–215 (1981).
doi: 10.1042/cs0610207
Ward Platt, M. & Deshpande, S. Metabolic adaptation at birth. Semin. Fetal Neonatal Med. 10, 341–350 (2005).
pubmed: 15916931
doi: 10.1016/j.siny.2005.04.001
de Boo, H. A. & Harding, J. E. Protein metabolism in preterm infants with particular reference to intrauterine growth restriction. Arch. Dis. Child Fetal Neonatal Ed. 92, F315–F319 (2007).
pubmed: 17585098
pmcid: 2675441
doi: 10.1136/adc.2006.099697
Tudehope, D., Vento, M., Bhutta, Z. & Pachi, P. Nutritional requirements and feeding recommendations for small for gestational age infants. J. Pediatr. 162, S81–S89 (2013).
pubmed: 23445853
doi: 10.1016/j.jpeds.2012.11.057
Thureen, P. J. Early aggressive nutrition in the neonate. Pediatr. Rev. 20, e45–e55 (1999).
pubmed: 10473666
doi: 10.1542/pir.20.9.e45
Committee on Nutrition. Nutritional needs of low-birth-weight infants. Pediatrics 75, 976–986 (1985).
doi: 10.1542/peds.75.5.976
Pereira-da-Silva, L., Virella, D. & Fusch, C. Nutritional assessment in preterm infants: a practical approach in the NICU. Nutrients 11, 1999 (2019).
pmcid: 6770216
doi: 10.3390/nu11091999
Maruyama, N. et al. Establishment of a highly sensitive sandwich ELISA for the N-terminal fragment of titin in urine. Sci. Rep. 6, 39375 (2016).
pubmed: 27991570
pmcid: 5171804
doi: 10.1038/srep39375
Matsuo, M., Awano, H., Maruyama, N. & Nishio, H. Titin fragment in urine: a noninvasive biomarker of muscle degradation. Adv. Clin. Chem. 90, 1–23 (2019).
pubmed: 31122607
doi: 10.1016/bs.acc.2019.01.001
Nakanishi, N. et al. Urinary titin N-fragment as a biomarker of muscle atrophy, intensive care unit-acquired weakness, and possible application for post-intensive care syndrome. J. Clin. Med. 10, 614 (2021).
pubmed: 33561946
pmcid: 7915692
doi: 10.3390/jcm10040614
Awano, H. et al. Diagnostic and clinical significance of the titin fragment in urine of Duchenne muscular dystrophy patients. Clin. Chim. Acta 476, 111–116 (2018).
pubmed: 29175173
doi: 10.1016/j.cca.2017.11.024
Nakanishi, N. et al. Urinary titin is a novel biomarker for muscle atrophy in nonsurgical critically ill patients: A two-center, prospective observational study. Crit. Care Med. 48, 1327–1333 (2020).
pubmed: 32706557
doi: 10.1097/CCM.0000000000004486
Ishihara, M. et al. Elevated urinary titin and its associated clinical outcomes after acute stroke. J. Stroke Cerebrovasc. Dis. 30, 1–6 (2020).
Whitehead, N. S. et al. Interventions to prevent iatrogenic anemia: a laboratory medicine best practices systematic review. Crit. Care 23, 278 (2019).
pubmed: 31399052
pmcid: 6688222
doi: 10.1186/s13054-019-2511-9
Matsuo, M., Shirakawa, T., Awano, H. & Nishio, H. Receiver operating curve analyses of urinary titin of healthy 3-y-old children may be a noninvasive screening method for Duchenne muscular dystrophy. Clin. Chim. Acta 486, 110–114 (2018).
pubmed: 30053403
doi: 10.1016/j.cca.2018.07.041
Fukushima, S. et al. Prediction of poor neurological development in patients with symptomatic congenital cytomegalovirus diseases after oral valganciclovir treatment. Brain Dev. 41, 743–750 (2019).
pubmed: 31072632
doi: 10.1016/j.braindev.2019.04.016
Shono, M. et al. Enhanced angiotensinogen expression in neonates during kidney development. Clin. Exp. Nephrol. 23, 537–543 (2019).
pubmed: 30353264
doi: 10.1007/s10157-018-1662-3
Gao, C. et al. Time to regain birth weight predicts neonatal growth velocity: a single-center experience. Clin. Nutr. ESPEN 38, 165–171 (2020).
pubmed: 32690152
pmcid: 8144885
doi: 10.1016/j.clnesp.2020.05.010
Morton, S. U. & Brodsky, D. Fetal physiology and the transition to extrauterine life. Clin. Perinatol. 43, 395–407 (2016).
pubmed: 27524443
pmcid: 4987541
doi: 10.1016/j.clp.2016.04.001
Taylor, A., Fisk, N. M. & Glover, V. Mode of delivery and subsequent stress response. Lancet 355, 120 (2000).
pubmed: 10675176
doi: 10.1016/S0140-6736(99)02549-0
Niklasson, A. et al. Growth in very preterm children: a longitudinal study. Pediatr. Res. 54, 899–905 (2003).
pubmed: 12930904
doi: 10.1203/01.PDR.0000091287.38691.EF
Cuestas, R. A. Jr. Creatine kinase isoenzymes in high-risk infants. Pediatr. Res. 14, 935–938 (1980).
pubmed: 7422397
doi: 10.1203/00006450-198008000-00008
Bertini, G., Elia, S. & Dani, C. Using ultrasound to examine muscle mass in preterm infants at term-equivalent age. Eur. J. Pediatr. 180, 461–468 (2021).
pubmed: 33083899
doi: 10.1007/s00431-020-03846-7
Yamaguchi, S., Suzuki, K., Kanda, K. & Okada, J. N-terminal fragments of titin in urine as a biomarker for eccentric exercise-induced muscle damage. J. Phys. Fit. Sports Med. 9, 21–29 (2020).
doi: 10.7600/jpfsm.9.21
Nakano, H. et al. Urine titin N-fragment as a biomarker of muscle injury for critical illness myopathy. Am. J. Respir. Crit. Care Med. 203, 515–518 (2021).
pubmed: 33030965
doi: 10.1164/rccm.202008-3089LE
Moyer-Mileur, L. J. Anthropometric and laboratory assessment of very low birth weight infants: The most helpful measurements and why. Semin. Perinatol. 31, 96–103 (2007).
pubmed: 17462494
doi: 10.1053/j.semperi.2007.02.006
Mathes, M. et al. Effect of increased enteral protein intake on plasma and urinary urea concentrations in preterm infants born at <32 weeks gestation and <1500 g birth weight enrolled in a randomized controlled trial—a secondary analysis. BMC Pediatr. 18, 154 (2018).
pubmed: 29739389
pmcid: 5941684
doi: 10.1186/s12887-018-1136-5
Ridout, E., Melara, D., Rottinghaus, S. & Thureen, P. J. Blood urea nitrogen concentration as a marker of amino-acid intolerance in neonates with birthweight less than 1250 g. J. Perinatol. 25, 130–133 (2005).
pubmed: 15510195
doi: 10.1038/sj.jp.7211215
Roggero, P. et al. Blood urea nitrogen concentrations in low-birth-weight preterm infants during parenteral and enteral nutrition. J. Pediatr. Gastroenterol. Nutr. 51, 213–215 (2010).
pubmed: 20479690
doi: 10.1097/MPG.0b013e3181cd270f
Elustondo, P. A. et al. Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria. J. Biol. Chem. 288, 25309–25317 (2013).
pubmed: 23873936
pmcid: 3757195
doi: 10.1074/jbc.M113.476648
Baxmann, A. C. et al. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clin. J. Am. Soc. Nephrol. 3, 348–354 (2008).
pubmed: 18235143
pmcid: 2390952
doi: 10.2215/CJN.02870707
Gluckman, P. D. & Hanson, M. A. Living with the past: evolution, development, and patterns of disease. Science 305, 1733–1736 (2004).
pubmed: 15375258
doi: 10.1126/science.1095292
Stephens, B. E. et al. First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics 123, 1337–1343 (2009).
pubmed: 19403500
doi: 10.1542/peds.2008-0211
Thureen, P. J., Melara, D., Fennessey, P. V. & Hay, W. W. Jr. Effect of low versus high intravenous amino acid intake on very low birth weight infants in the early neonatal period. Pediatr. Res 53, 24–32 (2003).
pubmed: 12508078
doi: 10.1203/00006450-200301000-00008
Vlaardingerbroek, H. et al. Safety and efficacy of early parenteral lipid and high-dose amino acid administration to very low birth weight infants. J. Pediatr. 163, 638–644 (2013). e631-635.
pubmed: 23660378
doi: 10.1016/j.jpeds.2013.03.059
Ramel, S. E., Brown, L. D. & Georgieff, M. K. The impact of neonatal illness on nutritional requirements-one size does not fit all. Curr. Pediatr. Rep. 2, 248–254 (2014).
pubmed: 25722954
pmcid: 4337785
doi: 10.1007/s40124-014-0059-3
Lucas, A. et al. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 108, 703–711 (2001).
pubmed: 11533340
doi: 10.1542/peds.108.3.703
Bhatia, J., Mena, P., Denne, S. & García, C. Evaluation of adequacy of protein and energy. J. Pediatr. 162, S31–S36 (2013).
pubmed: 23445846
doi: 10.1016/j.jpeds.2012.11.051
Power, V. A. et al. Nutrition, growth, brain volume, and neurodevelopment in very preterm children. J. Pediatr. 215, 50–55 (2019).
pubmed: 31561956
doi: 10.1016/j.jpeds.2019.08.031