Design, implementation and initial findings of COVID-19 research in the Rotterdam Study: leveraging existing infrastructure for population-based investigations on an emerging disease.
COVID-19
Design
Methods
Population-based
Prevalence
Risk factors
Journal
European journal of epidemiology
ISSN: 1573-7284
Titre abrégé: Eur J Epidemiol
Pays: Netherlands
ID NLM: 8508062
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
18
06
2021
accepted:
09
07
2021
pubmed:
19
7
2021
medline:
14
8
2021
entrez:
18
7
2021
Statut:
ppublish
Résumé
The Rotterdam Study is an ongoing prospective, population-based cohort study that started in 1989 in the city of Rotterdam, the Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. It focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. In response to the COVID-19 pandemic, a substudy was designed and embedded within the Rotterdam Study. On the 20th of April, 2020, all living non-institutionalized participants of the Rotterdam Study (n = 8732) were invited to participate in this sub-study by filling out a series of questionnaires administered over a period of 8 months. These questionnaires included questions on COVID-19 related symptoms and risk factors, characterization of lifestyle and mental health changes, and determination of health care seeking and health care avoiding behavior during the pandemic. As of May 2021, the questionnaire had been sent out repeatedly for a total of six times with an overall response rate of 76%. This article provides an overview of the rationale, design, and implementation of this sub-study nested within the Rotterdam Study. Finally, initial results on participant characteristics and prevalence of COVID-19 in this community-dwelling population are shown.
Identifiants
pubmed: 34275020
doi: 10.1007/s10654-021-00789-7
pii: 10.1007/s10654-021-00789-7
pmc: PMC8286166
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
649-654Subventions
Organisme : ZonMw
ID : 10430022010016
Pays : Netherlands
Organisme : ZonMw
ID : 10430022010016
Pays : Netherlands
Informations de copyright
© 2021. The Author(s).
Références
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782–93. 2768391. https://doi.org/10.1001/jama.2020.12839
Kola L, Kohrt BA, Hanlon C, et al. COVID-19 mental health impact and responses in low-income and middle-income countries: reimagining global mental health. Lancet Psychiatry. 2021;8(6):535–50. https://doi.org/10.1016/S2215-0366(21)00025-0 .
doi: 10.1016/S2215-0366(21)00025-0
pubmed: 33639109
Pierce M, McManus S, Hope H, et al. Mental health responses to the COVID-19 pandemic: a latent class trajectory analysis using longitudinal UK data. Lancet Psychiatry. 2021. https://doi.org/10.1016/S2215-0366(21)00151-6 .
doi: 10.1016/S2215-0366(21)00151-6
pubmed: 33965057
Licher S, Heshmatollah A, van der Willik KD, et al. Lifetime risk and multimorbidity of non-communicable diseases and disease-free life expectancy in the general population: A population-based cohort study. PLoS Med. 2019;16(2): e1002741. https://doi.org/10.1371/journal.pmed.1002741 . PMEDICINE-D-18-03486
doi: 10.1371/journal.pmed.1002741.
pubmed: 30716101
pmcid: 6361416
Terzikhan N, Hofman A, Goudsmit J, Ikram MA. External validity of phase III trials on vaccines against SARS-CoV-2 to a middle-aged and elderly Western European population. Eur J Epidemiol. 2021;36(3):319–24. https://doi.org/10.1007/s10654-021-00729-5 .
doi: 10.1007/s10654-021-00729-5
pubmed: 33634346
pmcid: 7906827
Ikram MA, Brusselle G, Ghanbari M, et al. Objectives, design and main findings until 2020 from the Rotterdam Study. Eur J Epidemiol. 2020;35(5):483–517. https://doi.org/10.1007/s10654-020-00640-5 .
doi: 10.1007/s10654-020-00640-5
pubmed: 32367290
pmcid: 7250962
Series BWP. Variation in government responses to COVID-19 University of Oxford. 2021. https://www.bsg.ox.ac.uk/research/publications/variation-government-responses-covid-19 . Accessed April 19th 2021.
Mc Intyre K, Lanting P, Deelen P, et al. Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort. BMJ Open. 2021;11(3): e044474. https://doi.org/10.1136/bmjopen-2020-044474 .
doi: 10.1136/bmjopen-2020-044474
pubmed: 33737436
Initiative C-HG. The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eur J Hum Genet. 2020;28(6):715–8. https://doi.org/10.1038/s41431-020-0636-6