Effect of Aerobic Exercise on White Matter Tract Microstructure in Young and Middle-Aged Healthy Adults.
aerobic exercise
aging
cardiorespiratory fitness
cognition
white matter microstructure
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
03
2021
accepted:
10
05
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Recent evidence suggests that being physically active can mitigate age-related white matter (WM) changes. In a randomized clinical trial, the effect of 6-month aerobic exercise (AE) or stretching/toning interventions on measures of WM microstructure (WMM) was assessed in a sample of 74 adults aged 20-67 years. Major WM pathways were reconstructed. No significant group-level change in WM tract microstructure following an AE training was observed. Without adjustment for multiple comparisons, an increase in fractional anisotropy (FA) and a decrease in mean diffusivity (MD) of the uncinate fasciculus were observed post-intervention in the AE group in comparison with the stretching group. In the AE group, a significant increase in cardiorespiratory fitness was measured but did not correlate with FA and MD change. The present results of this study are in accordance with similar studies in healthy adults that did not show significant benefit on WMM after participating in an AE program.
Identifiants
pubmed: 34276329
doi: 10.3389/fnhum.2021.681634
pmc: PMC8283503
doi:
Banques de données
ClinicalTrials.gov
['NCT01179958']
Types de publication
Journal Article
Langues
eng
Pagination
681634Subventions
Organisme : NIA NIH HHS
ID : K01 AG051777
Pays : United States
Informations de copyright
Copyright © 2021 Predovan, Gazes, Lee, Li, Sloan and Stern.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurobiol Aging. 2019 Aug;80:56-70
pubmed: 31103633
Ann Clin Transl Neurol. 2015 Jun;2(6):688-98
pubmed: 26125043
PLoS One. 2012;7(8):e44195
pubmed: 22952926
Arch Clin Neuropsychol. 2013 Jun;28(4):320-30
pubmed: 23552802
Behav Brain Res. 2019 Nov 5;373:112042
pubmed: 31279793
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
pubmed: 17167157
Neurology. 2015 Jun 9;84(23):2347-53
pubmed: 25957331
Front Behav Neurosci. 2016 Jun 15;10:124
pubmed: 27378875
Neuroimage. 2012 Jan 16;59(2):1514-23
pubmed: 21875674
Neurobiol Aging. 2019 Jul;79:119-130
pubmed: 31051329
J Clin Med. 2019 Jun 21;8(6):
pubmed: 31234307
Neuroimage. 2011 Jul 1;57(1):19-21
pubmed: 21376812
Brain Connect. 2011;1(6):423-46
pubmed: 22432902
Ann Clin Res. 1971 Dec;3(6):404-32
pubmed: 4945367
J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):176-80
pubmed: 12586857
Behav Brain Res. 2018 Feb 26;339:249-254
pubmed: 29126930
Neuroimage. 2016 Feb 15;127:277-286
pubmed: 26717853
Neuropsychologia. 2009 Feb;47(3):916-27
pubmed: 19166865
Front Neuroendocrinol. 2017 Jul;46:71-85
pubmed: 28442274
Sports Med. 2019 Feb;49(Suppl 1):69-85
pubmed: 30671905
J Neurosci. 2013 Dec 11;33(50):19499-503
pubmed: 24336716
Neuroimage. 2016 May 1;131:91-101
pubmed: 26439513
Neurology. 2019 Feb 26;92(9):e905-e916
pubmed: 30700591
Front Aging Neurosci. 2017 Mar 16;9:59
pubmed: 28360853
Trends Neurosci. 2020 Jul;43(7):533-543
pubmed: 32409017
Neuroimage. 2012 Jul 16;61(4):1402-18
pubmed: 22430496
Front Neuroinform. 2011 Oct 14;5:23
pubmed: 22016733
Neuron. 2017 Dec 20;96(6):1239-1251
pubmed: 29268094
Front Aging Neurosci. 2018 Sep 19;10:275
pubmed: 30283329
Neurobiol Aging. 2019 Feb;74:46-55
pubmed: 30415127
AJNR Am J Neuroradiol. 2007 Feb;28(2):226-35
pubmed: 17296985
Neuroimage. 2016 May 1;131:81-90
pubmed: 26477656
Br J Sports Med. 2018 Feb;52(3):154-160
pubmed: 28438770
Eur Heart J. 2019 Jul 21;40(28):2290-2300
pubmed: 30854560
Brain Res. 2014 Nov 7;1588:63-72
pubmed: 25204690
Cereb Cortex. 2004 Jan;14(1):11-22
pubmed: 14654453
Hum Brain Mapp. 2013 Nov;34(11):2972-85
pubmed: 22674729
Nat Commun. 2016 Dec 15;7:13629
pubmed: 27976682
Brain Imaging Behav. 2019 Oct;13(5):1444-1452
pubmed: 30187206
Hum Brain Mapp. 2019 May;40(7):2252-2268
pubmed: 30673158
Neuroimage. 2017 Oct 15;160:32-40
pubmed: 28159687
J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):236-243
pubmed: 30285083
Nat Neurosci. 2009 Nov;12(11):1370-1
pubmed: 19820707
J Sci Med Sport. 2018 May;21(5):489-494
pubmed: 28919495
Neuroimage. 2010 Dec;53(4):1181-96
pubmed: 20637289
Neuron. 2006 Sep 7;51(5):527-39
pubmed: 16950152
Neurology. 2012 Oct 23;79(17):1802-8
pubmed: 23091073
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Neurosci Biobehav Rev. 2018 May;88:177-186
pubmed: 29572187
Med Sci Sports Exerc. 2019 Jun;51(6):1242-1251
pubmed: 31095081
Cereb Cortex. 2015 Feb;25(2):396-405
pubmed: 23985135
Neuroimage. 2010 Feb 1;49(3):2104-12
pubmed: 19782758
Sports Med. 2003;33(12):877-88
pubmed: 12974656
J Alzheimers Dis. 2020;73(2):489-501
pubmed: 31796677