The Role of C-reactive Protein in Patient Risk Stratification and Treatment.
C-reactive protein
Inflammation
coronary artery disease
primary prevention
secondary prevention
Journal
European cardiology
ISSN: 1758-3764
Titre abrégé: Eur Cardiol
Pays: England
ID NLM: 101574780
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
07
12
2020
accepted:
15
03
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Atherosclerosis is a chronic inflammatory disease. Several circulating inflammatory markers have been proposed for clinical use due to their ability to predict future cardiovascular events and may be useful for identifying people at high risk who might benefit from specific treatment to reduce this risk. Moreover, the identification of new therapeutic targets will allow the development of drugs that can help reduce the high residual risk of recurrence of cardiovascular events in patients with coronary artery disease. The clinical benefits of reducing recurrent major cardiovascular events recently shown by canakinumab and colchicine have renewed the cardiology community's interest in inflammation as an aetiopathogenic mechanism for atherosclerosis. This review explores the use of C-reactive protein, which is the most frequently studied biomarker in this context; the concept of residual risk in primary and secondary cardiovascular prevention; and the current recommendations in international guidelines regarding the role of this inflammatory biomarker in cardiovascular risk stratification.
Identifiants
pubmed: 34276813
doi: 10.15420/ecr.2020.49
pmc: PMC8280753
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e28Informations de copyright
Copyright © 2021, Radcliffe Cardiology.
Déclaration de conflit d'intérêts
Disclosure: PA is an associate editor and RAE is on the European Cardiology Review editorial board, which did not affect the peer-review process. All other authors have no conflicts of interest to declare.
Références
Cardiovasc Res. 2019 Jan 1;115(1):10-19
pubmed: 30534957
Eur Heart J. 2020 Jan 1;41(1):111-188
pubmed: 31504418
J Am Coll Cardiol. 2007 Nov 20;50(21):2061-7
pubmed: 18021874
J Am Coll Cardiol. 2002 Oct 16;40(8):1375-82
pubmed: 12392824
Circulation. 2007 Feb 27;115(8):981-9
pubmed: 17283264
Lancet. 2018 Jan 27;391(10118):319-328
pubmed: 29146124
Circulation. 1996 Nov 15;94(10):2373-80
pubmed: 8921776
Eur Heart J. 2004 Mar;25(5):401-8
pubmed: 15033252
Lancet. 2008 May 24;371(9626):1761-8
pubmed: 18502300
J Am Coll Cardiol. 2016 Jan 26;67(3):344-6
pubmed: 26796402
Eur Heart J. 2018 Oct 7;39(38):3499-3507
pubmed: 30165610
Circulation. 2006 Jul 25;114(4):281-8
pubmed: 16847150
J Am Coll Cardiol. 2002 Feb 20;39(4):632-7
pubmed: 11849862
Molecules. 2019 May 30;24(11):
pubmed: 31151201
Circ Res. 2014 Jun 6;114(12):1867-79
pubmed: 24902971
N Engl J Med. 2014 May 1;370(18):1702-11
pubmed: 24678955
Int J Cardiol. 2006 May 10;109(2):248-56
pubmed: 16055214
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Circulation. 2018 Jul 10;138(2):131-140
pubmed: 29530884
N Engl J Med. 2000 Oct 19;343(16):1139-47
pubmed: 11036119
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
Eur Heart J. 2016 Jun 7;37(22):1720-2
pubmed: 26908943
Heart Lung Circ. 2019 May;28(5):667-677
pubmed: 30468147
Circulation. 2015 Sep 29;132(13):1224-33
pubmed: 26330412
N Engl J Med. 2008 Nov 20;359(21):2195-207
pubmed: 18997196
J Am Coll Cardiol. 2016 Feb 16;67(6):712-723
pubmed: 26868696
Rev Port Cardiol. 2013 Feb;32(2):117-22
pubmed: 23337430
Arq Bras Cardiol. 2011 Jan;96(1):13-7
pubmed: 21152699
Nat Commun. 2017 Jun 28;8:15986
pubmed: 28656979
Circulation. 2020 Nov 17;142(20):1996-1998
pubmed: 32864998
JAMA. 2001 Jul 4;286(1):64-70
pubmed: 11434828
Heart. 2004 Aug;90(8):847-52
pubmed: 15253949
J Am Coll Cardiol. 2000 May;35(6):1535-42
pubmed: 10807457
J Am Heart Assoc. 2017 Oct 24;6(10):
pubmed: 29066452
JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):305-316
pubmed: 29055633
Circulation. 2002 Apr 16;105(15):1760-3
pubmed: 11956114
Atherosclerosis. 2009 May;204(1):239-43
pubmed: 18823889
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
N Engl J Med. 1994 Aug 18;331(7):417-24
pubmed: 7880233
Circulation. 2018 Jul 10;138(2):141-149
pubmed: 29716940
J Am Coll Cardiol. 2019 May 21;73(19):2401-2409
pubmed: 31097159
JAMA Cardiol. 2019 Apr 1;4(4):314-320
pubmed: 30840024
Eur Heart J. 2015 Feb 7;36(6):377-84
pubmed: 25079365
Clin Cardiol. 2018 Sep;41(9):1201-1206
pubmed: 29952015
Am J Cardiol. 2004 Sep 15;94(6):766-9
pubmed: 15374783
N Engl J Med. 2018 Nov 29;379(22):2097-2107
pubmed: 30403574
JAMA. 2016 Dec 13;316(22):2373-2384
pubmed: 27846344
J Am Heart Assoc. 2014 Jul 10;3(4):
pubmed: 25012289
Eur Heart J. 2021 Jan 1;42(1):113-131
pubmed: 32176778
N Engl J Med. 2020 Nov 5;383(19):1838-1847
pubmed: 32865380
N Engl J Med. 2017 May 4;376(18):1713-1722
pubmed: 28304224
Am J Med. 2004 Mar 22;116 Suppl 6A:9S-16S
pubmed: 15050187
JACC Cardiovasc Imaging. 2015 Apr;8(4):493-494
pubmed: 25457756
Circulation. 2016 Nov 8;134(19):1419-1429
pubmed: 27682883
Circulation. 1999 Feb 23;99(7):861-6
pubmed: 10027806
Lancet. 2010 Jan 9;375(9709):132-40
pubmed: 20031199
Circulation. 2020 Mar 3;141(9):e139-e596
pubmed: 31992061
N Engl J Med. 2005 Jan 6;352(1):20-8
pubmed: 15635109
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Circulation. 2001 Mar 6;103(9):1194-7
pubmed: 11238260
Eur Heart J. 2007 Apr;28(7):806-13
pubmed: 17403721
Circulation. 2014 Jul 1;130(1):35-50
pubmed: 24982116
JAMA. 2014 Sep 10;312(10):1006-15
pubmed: 25173516
N Engl J Med. 2001 Jun 28;344(26):1959-65
pubmed: 11430324
Circulation. 1999 Jan 19;99(2):237-42
pubmed: 9892589
Circulation. 2000 Oct 31;102(18):2165-8
pubmed: 11056086
Am J Cardiol. 2007 Mar 15;99(6):805-7
pubmed: 17350370
Heart. 2004 Mar;90(3):264-9
pubmed: 14966041
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
Eur Heart J. 2018 Oct 21;39(40):3641-3653
pubmed: 30165636
Eur Heart J. 2011 Jul;32(14):1769-818
pubmed: 21712404
Lancet. 2012 Mar 31;379(9822):1214-24
pubmed: 22421340
PLoS One. 2008 Aug 20;3(8):e3011
pubmed: 18714384
N Engl J Med. 2005 Jan 6;352(1):29-38
pubmed: 15635110
J Am Heart Assoc. 2016 May 20;5(5):
pubmed: 27207959
Circulation. 2019 Sep 10;140(11):e596-e646
pubmed: 30879355
JAMA. 2014 Jan 15;311(3):252-62
pubmed: 24247616
JAMA. 2016 Apr 19;315(15):1591-9
pubmed: 27043082
J Clin Invest. 1978 Feb;61(2):235-42
pubmed: 621273
Clin Chem. 2001 May;47(5):882-6
pubmed: 11325892
Circulation. 1998 Aug 25;98(8):731-3
pubmed: 9727541
Circ Res. 2014 Feb 14;114(4):672-6
pubmed: 24337102
J Biol Chem. 2004 Nov 19;279(47):48487-90
pubmed: 15337754
J Am Coll Cardiol. 2003 Mar 19;41(6):916-24
pubmed: 12651034
Clin Chem. 2007 Oct;53(10):1800-7
pubmed: 17717132
J Am Coll Cardiol. 2013 Jan 29;61(4):404-410
pubmed: 23265346
Circulation. 2004 Sep 28;110(13):1747-53
pubmed: 15381646