Histamine is involved in the regulation of collagen content in cultured heart myofibroblasts via H
cell culture
collagen
heart
histamine
histamine receptor
myofibroblast
Journal
Biomedical reports
ISSN: 2049-9442
Titre abrégé: Biomed Rep
Pays: England
ID NLM: 101613227
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
23
11
2020
accepted:
07
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
ppublish
Résumé
Histamine is involved in the regulation of collagen metabolism during healing following a myocardial infarction; however, its effects on the intact heart tissue is unknown. The aim of the present study was to determine whether histamine may influence collagen content in cells isolated from intact heart, and to identify the histamine receptor involved in the regulation of collagen deposition. Cells were isolated from intact rat hearts and subjected to identification by flow cytometry. The effects of histamine and its receptor agonists and antagonists were investigated. The heart cells were found to be actin, desmin and vimentin positive. Histamine (used at a concentrations of 1x10
Identifiants
pubmed: 34276989
doi: 10.3892/br.2021.1447
pii: BR-0-0-01447
pmc: PMC8278034
doi:
Types de publication
Journal Article
Langues
eng
Pagination
71Informations de copyright
Copyright © 2020, Spandidos Publications.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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