Curcumin-loaded nanocomplexes: Acute and chronic toxicity studies in mice and hamsters.
Curcumin
ER stress
LD50
NOAEL
Safety assessment
Journal
Toxicology reports
ISSN: 2214-7500
Titre abrégé: Toxicol Rep
Pays: Ireland
ID NLM: 101630272
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
04
2021
revised:
15
06
2021
accepted:
24
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
We recently developed a modified solid dispersion of curcumin-loaded nanocomplexes (CNCs) in gums which promoted the prolonged and sustained release of curcumin. However, its safety assessment has not yet been investigated. Here, acute and chronic toxicities of CNCs were assayed using mice and hamsters. CNCs were orally administered to the animals. Doses of CNCs used for acute toxicity testing were 0.1, 1.1, 11.0 g/kg body weight for mice and 0.2, 2.1 and 21.4 g/kg body weight for hamsters. Doses of CNCs for chronic toxicity testing were 0.09, 0.27, 0.8 g/kg body weight/day for mice and 0.18, 0.54 and 1.61 g/kg body weight/day for hamsters. This regimen was followed daily for 6 months. Low and medium doses of CNCs did not induce any side effects in acute and chronic toxicity tests in either animal species. However, in acute toxicity testing, the organ-weight to body-weight ratio of spleen was significantly increased in mice treated with 11 g/kg body weight along with elevated levels of some biochemical parameters. There was a significant increase in organ-weight to body-weight ratios of stomach, liver and heart in hamsters treated with 21.4 g/kg body weight, but no elevated levels of biochemical parameters. Oral LD
Identifiants
pubmed: 34277359
doi: 10.1016/j.toxrep.2021.06.021
pii: S2214-7500(21)00127-X
pmc: PMC8267493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1346-1357Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
Welltech Biotechnology Co., Ltd, Thailand, the producer and supplier of CNCs and BNCs, had no part in the planning and conducting the acute and chronic toxicity testing in this project. All authors declare no conflict of interest.
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