The Long Noncoding RNA LINC00665 Facilitates c-Myc Transcriptional Activity
LINC00665
LUAD
MYCBP
MiR-195-5p
lncRNA
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
02
2021
accepted:
15
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Long noncoding RNAs (lncRNAs) have recently received growing substantial attention in cancer research due to their important roles in various cancer types. However, the underlying mechanisms and functions of lncRNAs, especially in lung adenocarcinoma (LUAD), remain elusive. Based on pan-cancer screening analyses, we identified that the noncoding RNA LINC00665 was up-regulated in lung adenocarcinoma, which was subsequently confirmed in clinical samples and cell lines. Higher expression of LINC00665 was positively associated with poor prognosis and advanced T stage. Next, using gain- and loss- of function approaches, we revealed that LINC00665 promotes cell proliferation, cell migration, invasion, and suppresses cell apoptosis in LUAD through
Identifiants
pubmed: 34277412
doi: 10.3389/fonc.2021.666551
pmc: PMC8281894
doi:
Types de publication
Journal Article
Langues
eng
Pagination
666551Informations de copyright
Copyright © 2021 Wang, Zhang, Wei, Wang, Zhang, Yang, Xia, Mao, Xu, Jiang and Dong.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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