Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias.
GCN2
general control non-derepressible 2
mTORC1
myeloid leukemias
non-essential amino acid
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
04
2021
accepted:
15
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Amino acid (AA) metabolism plays an important role in many cellular processes including energy production, immune function, and purine and pyrimidine synthesis. Cancer cells therefore require increased AA uptake and undergo metabolic reprogramming to satisfy the energy demand associated with their rapid proliferation. Like many other cancers, myeloid leukemias are vulnerable to specific therapeutic strategies targeting metabolic dependencies. Herein, our review provides a comprehensive overview and TCGA data analysis of biosynthetic enzymes required for non-essential AA synthesis and their dysregulation in myeloid leukemias. Furthermore, we discuss the role of the general control nonderepressible 2 (GCN2) and-mammalian target of rapamycin (mTOR) pathways of AA sensing on metabolic vulnerability and drug resistance.
Identifiants
pubmed: 34277440
doi: 10.3389/fonc.2021.694526
pmc: PMC8281237
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
694526Subventions
Organisme : NCI NIH HHS
ID : R01 CA216815
Pays : United States
Informations de copyright
Copyright © 2021 Bhingarkar, Vangapandu, Rathod, Hoshitsuki and Fernandez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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