Trehalose-Induced Remodelling of the Human Microbiota Affects


Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2021
Historique:
received: 26 02 2021
accepted: 02 06 2021
entrez: 19 7 2021
pubmed: 20 7 2021
medline: 24 7 2021
Statut: epublish

Résumé

Within the human intestinal tract, dietary, microbial- and host-derived compounds are used as signals by many pathogenic organisms, including

Identifiants

pubmed: 34277467
doi: 10.3389/fcimb.2021.670935
pmc: PMC8284250
doi:

Substances chimiques

Anti-Bacterial Agents 0
Trehalose B8WCK70T7I

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

670935

Informations de copyright

Copyright © 2021 Buckley, Moura, Arai, Spittal, Clark, Nishida, Harris, Bentley, Davis, Wang, Mitra, Higashiyama and Wilcox.

Déclaration de conflit d'intérêts

MW has received honoraria for consultancy work, financial support to attend meetings and research funding from Astellas, AstraZeneca, Abbott, Actelion, Alere, AstraZeneca, Bayer, bioMérieux, Cerexa, Cubist, Da Volterra, Durata, Merck, Nabriva Therapeutics plc, Pfizer, Qiagen, Roche, Seres Therapeutics Inc., Synthetic Biologics, Summit and The Medicines Company. IBM has received support to attend meetings from Techlabs Inc. AB has received research funding from Seres Therapeutics Inc., Motif Biosciences plc., Nabriva Therapeutics plc, Tetraphase Pharmaceuticals, and Hayashibara Co. Ltd. Authors NA, YN and TH were employed by Hayashibara Co. Ltd./NAGASE Group. The authors declare that this study received funding from Hayashibara Co. Ltd. The funder had the following involvement in the study: measuring trehalose and glucose concentrations from each vessel in all of the gut models by HPLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Anthony M Buckley (AM)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Ines B Moura (IB)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Norie Arai (N)

R&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.

William Spittal (W)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Emma Clark (E)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Yoshihiro Nishida (Y)

R&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.

Hannah C Harris (HC)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Karen Bentley (K)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Georgina Davis (G)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Dapeng Wang (D)

LeedsOmics, University of Leeds, Leeds, United Kingdom.

Suparna Mitra (S)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

Takanobu Higashiyama (T)

R&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.

Mark H Wilcox (MH)

Healthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.

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Classifications MeSH