SISTEMA: A large and standardized collection of transcriptome data sets for human pluripotent stem cell research.
Database
Human Pluripotent Stem Cells
Transcriptomic
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
21
12
2020
revised:
29
03
2021
accepted:
21
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Human pluripotent stem cells have ushered in an exciting new era for disease modeling, drug discovery, and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by robust data sets and complementary resources that are easily accessed and interrogated by the stem cell community. In this context, we present SISTEMA, a quality-controlled curated gene expression database, built on a valuable catalog of human pluripotent stem cell lines, and their derivatives for which transcriptomic analyses have been generated using a single experimental pipeline. SISTEMA functions as a one-step resource that will assist the stem cell community to easily evaluate the expression level for genes of interest, while comparing them across different hPSC lines, cell types, pathological conditions, or after pharmacological treatments.
Identifiants
pubmed: 34278269
doi: 10.1016/j.isci.2021.102767
pii: S2589-0042(21)00735-5
pmc: PMC8271161
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102767Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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