Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action.
COVID-19
PPI
SARS-CoV-2
combination therapy
complementary exposure
drug repositioning
drug targets
mechanisms of action
network pharmacology
protein-protein interaction
Journal
Patterns (New York, N.Y.)
ISSN: 2666-3899
Titre abrégé: Patterns (N Y)
Pays: United States
ID NLM: 101767765
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
20
03
2021
revised:
12
04
2021
accepted:
12
07
2021
pubmed:
20
7
2021
medline:
20
7
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
An effective monotherapy to target the complex and multifactorial pathology of SARS-CoV-2 infection poses a challenge to drug repositioning, which can be improved by combination therapy. We developed an online network pharmacology-based drug repositioning platform, COVID-CDR (http://vafaeelab.com/COVID19repositioning.html), that enables a visual and quantitative investigation of the interplay between the primary drug targets and the SARS-CoV-2-host interactome in the human protein-protein interaction network. COVID-CDR prioritizes drug combinations with potential to act synergistically through different, yet potentially complementary, pathways. It provides the options for understanding multi-evidence drug-pair similarity scores along with several other relevant information on individual drugs or drug pairs. Overall, COVID-CDR is a first-of-its-kind online platform that provides a systematic approach for pre-clinical
Identifiants
pubmed: 34278363
doi: 10.1016/j.patter.2021.100325
pii: S2666-3899(21)00173-2
pmc: PMC8277549
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100325Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
F.V. is a member of Patterns journal advisory board. The authors declare no other competing interests.
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