Peutz-Jeghers syndrome complicated by gastric-type cervical mucinous carcinoma and primary peritoneal carcinoma.
Peutz-Jeghers syndrome
gastric type
high-grade serous carcinoma
mucinous carcinoma
primary peritoneal carcinoma
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
19
06
2021
received:
30
03
2021
accepted:
07
07
2021
pubmed:
20
7
2021
medline:
6
10
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
A 45-year-old multiparous woman with a STK11 mutation and a history of Peutz-Jeghers syndrome underwent radical hysterectomy and bilateral salpingo-oophorectomy for a gastric-type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker levels, and computed tomography showed multiple calcifications in the peritoneum. Peritoneal dissemination was suspected, and a laparoscopic biopsy was performed. Histopathology showed a high-grade serous carcinoma, and the patient was diagnosed with a metachronous stage IIIC primary peritoneal carcinoma. She had no BRCA1/2 mutation. After chemotherapy with docetaxel, carboplatin, and bevacizumab, she achieved complete remission.
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
3732-3736Informations de copyright
© 2021 Japan Society of Obstetrics and Gynecology.
Références
Banno K, Kisu I, Yanokura M, et al. Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (review). Oncol Lett. 2013;6:1184-8.
Hearle N, Schumacher V, Menko FH, Olschwang S, Boardman LA, Gille JJP, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006;12:3209-15.
Hideyuki I, Tajima Y, Gonda T, Kumamoto K, Ishibashi K, Iwama T. Update on our investigation of malignant tumors associated with Peutz-Jeghers syndrome in Japan. Surg Today. 2016;46:1231-42.
Guzman P, Roa I, Villaseca M, Roa JC, Araya JC. Peritoneal pseudomyxoma in a child with a gallbladder Peutz-Jeghers-like hamartomatous polyp: a case report. J Pediatr Surg. 1998;33:1320-2.
Iwamuro M, Toyokawa T, Moritou Y, Matsueda K, Hori S, Yoshioka M, et al. Peutz-Jeghers syndrome and cancer: a retrospective study in 14 Japanese patients with Peutz-Jeghers syndrome. Nihon Shokakibyo Gakkai Zasshi. 2019;116:1015-21.
The Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609-15.
Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, et al. High grade serous ovarian carcinomas originate in the fallopian tube. Nat Commun. 2017;8:1093.
Medeiros F, Muto MG, Lee Y, Elvin JA, Callahan MJ, Feltmate C, et al. The tubal fimbria is a preferred site for early adenocarcinoma in woman with familial ovarian cancer syndrome. Am J Surg Pathol. 2006;30:230-6.
Stanciu PI, Ind TEJ, Barton DPJ, Butler JB, Vroobel KM, Attygalle AD, et al. Development of peritoneal carcinoma in women diagnosed with serous tubal intraepithelial carcinoma (STIC) following risk-reducing salpingo-oophorectomy (RRSO). J Ovarian Res. 2019;12:50.
Rabban JT, Garg K, Crawford B, Chen LM, Zaloudek CJ. Early detection of high-grade tubal serous carcinoma in woman at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery. Am J Surg Pathol. 2014;38:729-42.
Hom LC, Kafkova S, Leonhardt K, Kellner C, Einenkel J. Serous tubal in situ carcinoma in primary peritoneal serous carcinoma. Int J Gynecol Pathol. 2013;32:339-44.
Finch AP, Lubinski J, Moller P, et al. Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol. 2014;32:1547-53.
Gilks CB, Young RH, Aguirre P, DeLellis RA, Scully RE. Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. Am J Surg Pathol. 1989;13:717-29.
Kwon JS, Tinker A, Pansegrau G, McAlpine J, Housty M, McCullum M, et al. Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers. Obstet Gynecol. 2013;121:14-24.