Identification of a Putative β-Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR).

Azides / chemical synthesis Humans Molecular Structure Receptors, Ghrelin / chemistry beta-Arrestins / agonists
ghrelin growth hormone secretagogue receptor (GHSR) medicinal chemistry receptors β-arrestin-biased agonist

Journal

ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013

Informations de publication

Date de publication:
19 11 2021
Historique:
revised: 14 07 2021
received: 07 05 2021
pubmed: 20 7 2021
medline: 25 2 2022
entrez: 19 7 2021
Statut: ppublish

Résumé

Ghrelin is a pleiotropic feeding hormone which also has a pivotal role in the central nervous system. Upon the activation of its receptor, growth hormone secretagogue receptor (GHSR), the Gα

Identifiants

DOI: 10.1002/cmdc.202100322 PMID: 34278724
pubmed: 34278724
doi: 10.1002/cmdc.202100322
doi:

Substances chimiques

Azides 0
Receptors, Ghrelin 0
beta-Arrestins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3463-3476

Subventions

Organisme : JPSP KAKENHI
ID : 16K18912
Organisme : Kitasato University

Informations de copyright

© 2021 Wiley-VCH GmbH.

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Auteurs

Fumika Karaki (F)

Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0002-3815-713X

Tomoya Oki (T)

Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Yuma Sakao (Y)

Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Noriko Sato (N)

Analytical Unit for Organic Chemistry, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Shigeto Hirayama (S)

Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Kanako Miyano (K)

Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Department of Pain Control Research, Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Yasuhito Uezono (Y)

Department of Pain Control Research, Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Supportive and Palliative Care Research Support Office, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa city, Chiba, 277-8577, Japan.

Hideaki Fujii (H)

Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Azotures › Identification of a Putative β-Arrestin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of a Putative β-Arrestin...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Identification of a Putative β-Arrestin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs à la ghréline › Identification of a Putative β-Arrestin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Arrestines › bêta-Arrestines › Identification of a Putative β-Arrestin...