Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands.
habits
heritability
neurodevelopment
phenotype
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
28
05
2021
received:
25
09
2020
accepted:
07
06
2021
pubmed:
20
7
2021
medline:
30
11
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p < 10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2373-2382Subventions
Organisme : Assistance Publique - Hôpitaux de Paris
Organisme : Centre National de la Recherche Scientifique
Organisme : DHU Protect
Organisme : Fondation de France
Organisme : Fondation Fondamental
Organisme : Fondation pour la Recherche Médicale
Organisme : Institut National de la Santé et de la Recherche Médicale
Organisme : Institut Pasteur
Organisme : Investissements d'Avenir program
ID : ANR-10-COHO-10-01
Organisme : Investissements d'Avenir program
ID : ANR-11-IDEX-0004-02
Organisme : Investissements d'Avenir program
ID : ANR-12-SAMA-0014
Organisme : Labex BioPsy
Organisme : Roche Institute for Research and Translational Medicine
Informations de copyright
© 2021 International Society for Autism Research, Wiley Periodicals LLC.
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