Mannose-Modified Chitosan Poly(lactic-
PLGA nanomicrospheres
delivery system
dendritic cells
mannose receptor
mannose-modified chitosan
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
03 Jul 2021
03 Jul 2021
Historique:
received:
16
06
2021
revised:
26
06
2021
accepted:
30
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
The mannose receptor (MAN-R)-targeted delivery system is commonly used to deliver antigens to macrophages or immature dendritic cells (DCs) to promote the efficiency of antigen presentation. To maximize the enhancement effects of chitosan (CS) and induce an efficient humoral and cellular immune response against an antigen, we encapsulated ovalbumin (OVA) in poly(lactic-co-glycolic acid) (PLGA) microspheres (MPs) and conjugated it with MAN-modified CS to obtain MAN-R-targeting nano-MPs (MAN-CS-OVA-PLGA-MPs). The physicochemical properties, drug loading rate, and immunomodulation activity of MAN-CS-OVA-PLGA-MPs were evaluated. In vitro, MAN-CS-OVA-PLGA-MPs (80 μg mL
Identifiants
pubmed: 34279352
pii: polym13132208
doi: 10.3390/polym13132208
pmc: PMC8271610
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 31872511
Organisme : Applied Basic Research Program of Sichuan Province
ID : 2021YJ0289
Organisme : Fundamental Research Funds for the Central Universities
ID : 2020NYB22
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