Hypocholesterolemic Effect of Blackcurrant (
atherosclerosis
cholesterol
lipoprotein
serum lipid
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Jul 2021
04 Jul 2021
Historique:
received:
15
06
2021
revised:
30
06
2021
accepted:
01
07
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Blackcurrant extract (BCE) ameliorates dyslipidemia in menopausal model animals and in elderly women at a risk of dyslipidemia. However, it is unknown whether the daily intake of BCE can prevent lipid abnormalities in healthy individuals. Lipids are essential for the body, but they also cause arteriosclerosis. In this noncomparative pilot study, we examined the effects of BCE administered for 29 days on serum lipids in young healthy women. Blood samples were collected before and on days 4 and 29 after BCE intake, and 20 lipoprotein fractions in the serum were separated using a gel-permeation high-performance liquid chromatography method to measure the triacylglycerol and cholesterol levels in lipoproteins. There were no effects on lipids on day 4 of BCE intake, but the total cholesterol level decreased on day 29. Furthermore, the levels of total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol were significantly decreased. These results suggest that the daily intake of BCE has a hypocholesterolemic effect in healthy women, and that it is effective in preventing atherosclerosis.
Identifiants
pubmed: 34279425
pii: molecules26134085
doi: 10.3390/molecules26134085
pmc: PMC8272003
pii:
doi:
Substances chimiques
Anticholesteremic Agents
0
Lipids
0
Lipoproteins
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20K02402
Organisme : Japan Science and Technology Agency
ID : JPMJTM19E5
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