Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Administration, Oral
Arachidonate 5-Lipoxygenase
/ genetics
Dose-Response Relationship, Drug
Drug Discovery
Humans
Inflammation
/ drug therapy
Lipoxygenase Inhibitors
/ administration & dosage
Molecular Docking Simulation
Molecular Structure
Recombinant Proteins
/ genetics
Structure-Activity Relationship
Vitamin E
/ administration & dosage
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
12 08 2021
12 08 2021
Historique:
pubmed:
20
7
2021
medline:
25
2
2023
entrez:
19
7
2021
Statut:
ppublish
Résumé
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (
Identifiants
pubmed: 34279935
doi: 10.1021/acs.jmedchem.1c00806
pmc: PMC8365602
doi:
Substances chimiques
Lipoxygenase Inhibitors
0
Recombinant Proteins
0
Vitamin E
1406-18-4
Arachidonate 5-Lipoxygenase
EC 1.13.11.34
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11496-11526Références
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