Steroid sulfatase in the mouse NIH-3T3 fibroblast cell line: Characterization, and downregulation by glucocorticoids.
Cortisol
Estrogens
Estrone sulfate
Fibroblasts
Glucocorticoids
Mouse
NIH-3T3 cells
Regulation
Steroid sulfatase
Sulfated steroids
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
21
12
2020
revised:
03
06
2021
accepted:
06
07
2021
pubmed:
20
7
2021
medline:
25
2
2022
entrez:
19
7
2021
Statut:
ppublish
Résumé
Steroid hormones often circulate in the blood as inactive sulfated forms, such as estrone sulfate and dehydroepiandrosterone sulfate. The enzyme steroid sulfatase (STS) converts these steroids into active forms, mainly estrogens, in peripheral tissues. We have previously characterized STS activity in human and mouse breast and bone tissues, and we have shown that STS can provide estrogens to these tissues from circulating sulfated precursors. This study was designed to characterize STS activity in a mouse fibroblast cell line (NIH-3T3). Using a radioactive estrone sulfate (E
Identifiants
pubmed: 34280393
pii: S0039-128X(21)00102-1
doi: 10.1016/j.steroids.2021.108890
pii:
doi:
Substances chimiques
Steryl-Sulfatase
EC 3.1.6.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108890Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.