Chemical exchange saturation transfer MRI in central nervous system tumours on a 1.5 T MR-Linac.

Brain Brain Neoplasms Central Nervous System Neoplasms / diagnostic imaging Humans Magnetic Resonance Imaging Phantoms, Imaging White Matter
Chemical exchange saturation transfer MR-Linac MRI guided therapy Quantitative MRI Radiation therapy Treatment monitoring

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
09 2021
Historique:
received: 17 03 2021
revised: 06 07 2021
accepted: 08 07 2021
pubmed: 20 7 2021
medline: 3 11 2021
entrez: 19 7 2021
Statut: ppublish

Résumé

To describe the implementation and initial results of using Chemical Exchange Saturation Transfer (CEST) for monitoring patients with central nervous system (CNS) tumours treated using a 1.5 tesla MR-guided radiotherapy system. CNS patients were treated with up to 30 fractions (total dose up to 60 Gy) using a 1.5 T Elekta Unity MR-Linac. CEST scans were obtained in 54 subjects at one or more time points during treatment. CEST metrics, including the amide magnetization transfer ratio (MTR The gross tumour volume (GTV) exhibited lower MTR CEST MRI using a 1.5 T MR-Linac was demonstrated to be feasible for in vivo imaging of CNS tumours. CEST images showed tumour/white-matter contrast, temporal CEST signal changes, and associations with tumour grade. These results show promise for the eventual goal of using metabolic imaging to inform the design of adaptive radiotherapy protocols.

Identifiants

DOI: 10.1016/j.radonc.2021.07.010 PMID: 34280403
pubmed: 34280403
pii: S0167-8140(21)06647-0
doi: 10.1016/j.radonc.2021.07.010
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

140-149

Subventions

Organisme : CIHR
ID : CIHR 156252
Pays : Canada
Organisme : CIHR
ID : 148660
Pays : Canada

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Rachel W Chan (RW)

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada. Electronic address: rchan@sri.utoronto.ca.

Liam S P Lawrence (LSP)

Department of Medical Biophysics, University of Toronto, Toronto, Canada.

Ryan T Oglesby (RT)

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.

Hanbo Chen (H)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

James Stewart (J)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Aimee Theriault (A)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Mikki Campbell (M)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Mark Ruschin (M)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Sten Myrehaug (S)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Eshetu G Atenafu (EG)

Department of Biostatistics, University Health Network, University of Toronto, Toronto, Canada.

Brian Keller (B)

Department of Biostatistics, University Health Network, University of Toronto, Toronto, Canada.

Brige Chugh (B)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Department of Physics, Ryerson University, Toronto, Canada.

Scott MacKenzie (S)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Chia-Lin Tseng (CL)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Jay Detsky (J)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Pejman J Maralani (PJ)

Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada.

Greg J Czarnota (GJ)

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Greg J Stanisz (GJ)

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.

Arjun Sahgal (A)

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Angus Z Lau (AZ)

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Équipement et fournitures › Fantômes en imagerie › Chemical exchange saturation transfer MRI in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Chemical exchange saturation transfer MRI in...