Pregnancy outcome predictors in antiphospholipid syndrome: A systematic review and meta-analysis.
Antiphospholipid syndrome
Meta-analysis
Obstetric outcome
Prediction
Pregnancy outcome
Prognostic
Journal
Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
15
05
2021
accepted:
21
05
2021
pubmed:
20
7
2021
medline:
29
9
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
To identify and assess the magnitude of effect of pregnancy outcome predictors in women with antiphospholipid syndrome (APS) by means of systematic review and meta-analysis. PubMed and Embase were searched (13th June 2020) for studies reporting on pre-pregnancy risk factors of pregnancy outcomes in APS patients. Literature screening and data extraction were conducted by two reviewers independently, in a blinded standardized manner. Pooled univariate odds ratios (OR) were computed using a random effects model. Heterogeneity was assessed by I The search yielded 3013 unique results; 27 records were included in this meta-analysis. Previous thrombosis was associated with a decreased live birth risk (OR 0.60, p < 0.01, I The results of this meta-analysis identified previous thrombosis, laboratory category I, triple positivity and lupus anticoagulant positivity as the most important predictors of adverse pregnancy outcomes. This up-to-date knowledge, can be used in preconception counseling and tailoring of obstetric care.
Identifiants
pubmed: 34280554
pii: S1568-9972(21)00174-9
doi: 10.1016/j.autrev.2021.102901
pii:
doi:
Substances chimiques
Lupus Coagulation Inhibitor
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102901Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.