Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review.
dysbiosis
gingivitis
inflammation
oral microbiota
periodontal disease
periodontal pathogens
placenta
pre-eclampsia
pregnancy
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
05 07 2021
05 07 2021
Historique:
received:
05
06
2021
revised:
01
07
2021
accepted:
03
07
2021
entrez:
20
7
2021
pubmed:
21
7
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Pre-eclampsia, the second most frequent direct source of maternal mortality, is a multisystem gestational disorder characterized by proteinuria and maternal hypertension after the 20th gestational week. Although the causes of pre-eclampsia are still discussed, research has suggested that the placenta has a central place in the pathogenesis of this disease. Moreover, current surveys indicated that periodontal disorders observed during the pregnancy and more particularly, periodontal pathogens could be link to the risk of pre-eclampsia. This article aims to review recent studies focusing on periodontal conditions and pathogens associated with pre-eclampsia. The process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Metabolic conditions, immunological changes, fluctuating progesterone and estrogen levels of the pregnant woman induce a dysbiosis of the oral microbiota and contribute to increase inflammation of periodontal tissues. Periodontal pathogens could diffuse through the bloodstream inducing a placenta inflammatory response as well as inflammatory molecules produced in response to periodontopathogens could migrate through the bloodstream leading to a placenta inflammatory response. Also, periodontopathogens can colonize the vaginal microbiota through the gastrointestinal tract or during oro-genital contacts. A cumulative bi-directional relationship between periodontal conditions, pathogens and the pre-eclampsia exists.
Sections du résumé
BACKGROUND
Pre-eclampsia, the second most frequent direct source of maternal mortality, is a multisystem gestational disorder characterized by proteinuria and maternal hypertension after the 20th gestational week. Although the causes of pre-eclampsia are still discussed, research has suggested that the placenta has a central place in the pathogenesis of this disease. Moreover, current surveys indicated that periodontal disorders observed during the pregnancy and more particularly, periodontal pathogens could be link to the risk of pre-eclampsia.
OBJECTIVES
This article aims to review recent studies focusing on periodontal conditions and pathogens associated with pre-eclampsia.
METHODS
The process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines.
RESULTS
Metabolic conditions, immunological changes, fluctuating progesterone and estrogen levels of the pregnant woman induce a dysbiosis of the oral microbiota and contribute to increase inflammation of periodontal tissues. Periodontal pathogens could diffuse through the bloodstream inducing a placenta inflammatory response as well as inflammatory molecules produced in response to periodontopathogens could migrate through the bloodstream leading to a placenta inflammatory response. Also, periodontopathogens can colonize the vaginal microbiota through the gastrointestinal tract or during oro-genital contacts.
CONCLUSION
A cumulative bi-directional relationship between periodontal conditions, pathogens and the pre-eclampsia exists.
Identifiants
pubmed: 34281133
pii: ijerph18137194
doi: 10.3390/ijerph18137194
pmc: PMC8297070
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Clin Periodontol. 2019 Jul;46(7):713-722
pubmed: 31115952
JDR Clin Trans Res. 2018 Jan;3(1):10-27
pubmed: 30370334
Microorganisms. 2019 Oct 09;7(10):
pubmed: 31600905
J Periodontol. 2007 Apr;78(4):670-6
pubmed: 17397314
Comput Struct Biotechnol J. 2021 Feb 27;19:1335-1360
pubmed: 33777334
J Dent Res. 2011 Mar;90(3):289-93
pubmed: 21041548
J Immunol. 2006 Jun 15;176(12):7371-8
pubmed: 16751381
Front Endocrinol (Lausanne). 2020 Sep 11;11:655
pubmed: 33042016
Int J Microbiol. 2014;2014:420149
pubmed: 24899898
J Clin Epidemiol. 2011 Apr;64(4):401-6
pubmed: 21208779
J Reprod Immunol. 2021 Jun;145:103293
pubmed: 33676065
J Huazhong Univ Sci Technolog Med Sci. 2014 Oct;34(5):729-735
pubmed: 25318884
Gut. 2002 May;50 Suppl 3:III54-9
pubmed: 11953334
Reprod Sci. 2009 Feb;16(2):206-15
pubmed: 19208789
J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S146-9
pubmed: 26604605
OMICS. 2014 Sep;18(9):582-90
pubmed: 24983467
J Obstet Gynaecol Res. 2015 May;41(5):662-9
pubmed: 25492799
J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):282-8
pubmed: 9949320
Clin Oral Investig. 2021 Apr 27;:
pubmed: 33904994
Microorganisms. 2020 Dec 15;8(12):
pubmed: 33333813
J Clin Med. 2021 Jan 07;10(2):
pubmed: 33430519
Int J Dent Hyg. 2018 Aug;16(3):389-396
pubmed: 28971569
J Obstet Gynaecol Res. 2017 Jan;43(1):16-22
pubmed: 28074549
Front Immunol. 2020 Oct 07;11:575197
pubmed: 33133091
Am J Obstet Gynecol. 2019 Nov;221(5):383-392.e3
pubmed: 31051120
Nanomaterials (Basel). 2020 Jan 13;10(1):
pubmed: 31941021
Fetal Matern Med Rev. 2014 Nov;25(3-4):332-338
pubmed: 27695204
PLoS One. 2013 Aug 19;8(8):e71387
pubmed: 23990948
Front Microbiol. 2016 Jul 14;7:1031
pubmed: 27471494
Eur J Oral Sci. 2016 Dec;124(6):566-571
pubmed: 27681016
Vasc Health Risk Manag. 2011;7:467-74
pubmed: 21822394
Sci Rep. 2019 Oct 22;9(1):15127
pubmed: 31641199
Int J Womens Health. 2017 Aug 08;9:551-559
pubmed: 28848365
Front Microbiol. 2016 Jun 02;7:840
pubmed: 27313576
PLoS One. 2013 Aug 12;8(8):e70901
pubmed: 23951033
Sci Rep. 2019 Aug 13;9(1):11762
pubmed: 31409865
J Clin Med. 2019 Oct 04;8(10):
pubmed: 31590294
J Hosp Med. 2019 Jun 19;14(7):416-418
pubmed: 31251164
Obstet Gynecol. 2019 Jan;133(1):1
pubmed: 30575675
PLoS One. 2017 May 19;12(5):e0178234
pubmed: 28538740
Mol Hum Reprod. 2000 Jul;6(7):661-4
pubmed: 10871654
Int J Environ Res Public Health. 2020 Oct 08;17(19):
pubmed: 33049972
J Int Soc Prev Community Dent. 2015 Mar-Apr;5(2):103-7
pubmed: 25992334
J Clin Periodontol. 2013 May;40(5):457-73
pubmed: 23557432
BMC Med Res Methodol. 2018 Nov 19;18(1):143
pubmed: 30453902
Periodontol 2000. 2013 Feb;61(1):125-59
pubmed: 23240947
Int J Environ Res Public Health. 2021 Feb 04;18(4):
pubmed: 33557327
Hypertension. 2016 Oct;68(4):964-73
pubmed: 27550919
PLoS One. 2014 May 28;9(5):e98271
pubmed: 24870125
J Clin Periodontol. 2016 Jun;43(6):512-9
pubmed: 26810391
J Periodontol. 2018 May;89(5):558-570
pubmed: 29520910
ISME J. 2013 May;7(5):1016-25
pubmed: 23303375
Periodontol 2000. 2018 Feb;76(1):7-15
pubmed: 29194794
J Clin Periodontol. 2015 May;42(5):431-9
pubmed: 25858047
Nat Rev Immunol. 2017 Aug;17(8):469-482
pubmed: 28627518
Plast Reconstr Surg. 2011 Jul;128(1):305-310
pubmed: 21701348
J Appl Oral Sci. 2020 Mar 27;28:e20190351
pubmed: 32236354
Cells. 2019 Sep 21;8(10):
pubmed: 31546660
J Clin Periodontol. 2015 Apr;42 Suppl 16:S92-105
pubmed: 25581718
Arch Gynecol Obstet. 2011 Apr;283(4):675-86
pubmed: 21120511
Front Cell Infect Microbiol. 2018 Feb 15;8:24
pubmed: 29497601
J Periodontol. 2011 Jun;82(6):885-92
pubmed: 21138356
Sci Transl Med. 2014 May 21;6(237):237ra65
pubmed: 24848255
Ann Med Health Sci Res. 2014 Nov;4(6):852-7
pubmed: 25506475
J Appl Oral Sci. 2014 Nov-Dec;22(6):528-33
pubmed: 25591021
Clin Obstet Gynecol. 2007 Dec;50(4):938-48
pubmed: 17982337
PLoS One. 2016 Jan 05;11(1):e0146157
pubmed: 26731111
J Investig Clin Dent. 2018 Feb;9(1):
pubmed: 28349674
J Clin Dent. 2017 Mar;28(1 Spec No A):A36-44
pubmed: 28422463
Ginekol Pol. 2020;91(3):158-164
pubmed: 32266957
Braz Oral Res. 2012 Sep-Oct;26(5):443-9
pubmed: 23018230
Nat Rev Microbiol. 2012 Oct;10(10):717-25
pubmed: 22941505
Mediators Inflamm. 2015;2015:623427
pubmed: 25873767
J Obstet Gynecol Neonatal Nurs. 2019 Mar;48(2):140-152
pubmed: 30597136
Expert Rev Anti Infect Ther. 2016 Jul;14(7):643-55
pubmed: 27224284
Best Pract Res Clin Obstet Gynaecol. 2011 Jun;25(3):301-11
pubmed: 21109492
PLoS One. 2019 Nov 22;14(11):e0225036
pubmed: 31756178
BMC Med. 2016 Dec 13;14(1):205
pubmed: 27955712
Sci Rep. 2020 Sep 3;10(1):14606
pubmed: 32884071
Ann Intern Med. 2018 Oct 2;169(7):467-473
pubmed: 30178033
Front Microbiol. 2020 Dec 02;11:591626
pubmed: 33343532
PLoS Med. 2019 Apr 12;16(4):e1002783
pubmed: 30978179
J Investig Clin Dent. 2017 Feb;8(1):
pubmed: 26345599
Open Dent J. 2009 Jun 05;3:114-9
pubmed: 19812718
Arch Gynecol Obstet. 2012 Mar;285(3):613-9
pubmed: 21830010
J Periodontal Res. 1995 Mar;30(2):124-31
pubmed: 7776153
J Oral Microbiol. 2017 Sep 13;10(1):1374153
pubmed: 29291034
Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H1-H10
pubmed: 31626558
Am J Obstet Gynecol. 2011 Mar;204(3):193-201
pubmed: 21094932
Front Microbiol. 2018 Oct 09;9:2360
pubmed: 30356676
Nucl Recept Signal. 2016 Jan 13;14:e001
pubmed: 26778927
J Clin Periodontol. 2015 Apr;42 Suppl 16:S71-6
pubmed: 25639826
J Clin Periodontol. 2001 Oct;28(10):937-46
pubmed: 11686812
Mayo Clin Proc. 2018 Nov;93(11):1664-1677
pubmed: 30392546
Cold Spring Harb Perspect Med. 2015 Mar 16;5(6):
pubmed: 25775922
J Clin Periodontol. 2003 Aug;30(8):671-81
pubmed: 12887335
MCN Am J Matern Child Nurs. 2017 Nov/Dec;42(6):310-317
pubmed: 28787280
J Periodontal Res. 2013 Dec;48(6):802-9
pubmed: 23711357
PLoS One. 2015 Feb 12;10(2):e0117472
pubmed: 25675430
Microorganisms. 2020 Dec 29;9(1):
pubmed: 33383903
J Periodontol. 2018 Jun;89 Suppl 1:S237-S248
pubmed: 29926943
J Tradit Complement Med. 2017 May 09;8(1):113-119
pubmed: 29321998
Mediators Inflamm. 2016;2016:4897890
pubmed: 27034591
J Clin Periodontol. 2016 Oct;43(10):807-15
pubmed: 27191801
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11060-5
pubmed: 26283357
SAGE Open Med. 2019 Apr 10;7:2050312119843700
pubmed: 31007914
PLoS One. 2017 Oct 10;12(10):e0185804
pubmed: 29016613
J Clin Periodontol. 2004 Sep;31(9):749-57
pubmed: 15312097