The Vitreous Ecosystem in Diabetic Retinopathy: Insight into the Patho-Mechanisms of Disease.

Aqueous Humor / metabolism Chemokines / metabolism Cytokines / metabolism Diabetes Mellitus / metabolism Diabetic Retinopathy / metabolism Humans Intercellular Signaling Peptides and Proteins / metabolism Interleukins / metabolism Vitreous Body / metabolism
cytokine diabetes eicosanoid interleukin retinopathy vitreous

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
01 Jul 2021
Historique:
received: 12 05 2021
revised: 10 06 2021
accepted: 14 06 2021
entrez: 20 7 2021
pubmed: 21 7 2021
medline: 7 8 2021
Statut: epublish

Résumé

Diabetic retinopathy is one of the leading causes of blindness in the world with the incidence of disease ever-increasing worldwide. The vitreous humor represents an extensive and complex interactive arena for cytokines in the diabetic eye. In recent decades, there has been significant progress in understanding this environment and its implications in disease pathophysiology. In this review, we investigate the vitreous ecosystem in diabetic retinopathy at the molecular level. Areas of concentration include: the current level of knowledge of growth factors, cytokine and chemokine mediators, and lipid-derived metabolites in the vitreous. We discuss the molecular patho-mechanisms of diabetic retinopathy based upon current vitreous research.

Identifiants

DOI: 10.3390/ijms22137142 PMID: 34281192 PMC: PMC8269048
pubmed: 34281192
pii: ijms22137142
doi: 10.3390/ijms22137142
pmc: PMC8269048
pii:
doi:

Substances chimiques

Chemokines 0
Cytokines 0
Intercellular Signaling Peptides and Proteins 0
Interleukins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Research to Prevent Blindness
ID : Departmental Grant

Références

Int J Ophthalmol. 2019 Nov 18;12(11):1688-1692
pubmed: 31741855
Diabetes Care. 2004 Mar;27(3):758-64
pubmed: 14988298
Mol Vis. 2006 Oct 02;12:1143-7
pubmed: 17093399
Am J Ophthalmol. 2007 Jan;143(1):175-6
pubmed: 17188064
Leuk Lymphoma. 2003 Apr;44(4):575-82
pubmed: 12769333
Graefes Arch Clin Exp Ophthalmol. 2009 Dec;247(12):1617-24
pubmed: 19639332
Arq Bras Oftalmol. 2019 Jul-Aug;82(4):275-282
pubmed: 30970121
Curr Pharm Des. 2018;24(27):3276-3281
pubmed: 30255745
Exp Eye Res. 2013 Mar;108:110-9
pubmed: 23276812
Biochem Biophys Res Commun. 1996 Apr 5;221(1):193-8
pubmed: 8660335
Diabetes. 2011 Feb;60(2):614-24
pubmed: 21228311
PLoS One. 2013 Dec 04;8(12):e82482
pubmed: 24324797
Br J Ophthalmol. 2007 Jul;91(7):885-7
pubmed: 17301120
Br J Ophthalmol. 2003 Aug;87(8):1038-42
pubmed: 12881351
Diabetes Res Clin Pract. 2003 Aug;61(2):93-101
pubmed: 12951277
Graefes Arch Clin Exp Ophthalmol. 2006 Jun;244(6):732-41
pubmed: 16341703
Graefes Arch Clin Exp Ophthalmol. 2005 Jan;243(1):3-8
pubmed: 15258777
Ophthalmology. 2003 Sep;110(9):1690-6
pubmed: 13129863
Clin Lipidol. 2012 Dec 1;7(6):661-675
pubmed: 23646066
Endocrinology. 1992 Aug;131(2):710-4
pubmed: 1639018
Curr Eye Res. 2017 Sep;42(9):1269-1272
pubmed: 28632410
Sci Rep. 2017 Apr 24;7:46698
pubmed: 28436420
Acta Ophthalmol. 2018 Jun;96(4):e460-e467
pubmed: 29098793
J Cell Physiol. 2003 Dec;197(3):453-62
pubmed: 14566975
Int J Mol Sci. 2019 Sep 25;20(19):
pubmed: 31557880
Graefes Arch Clin Exp Ophthalmol. 2008 Dec;246(12):1665-70
pubmed: 18682976
Turk J Med Sci. 2018 Aug 16;48(4):833-839
pubmed: 30119160
Surv Ophthalmol. 2019 Nov - Dec;64(6):780-809
pubmed: 31077688
Vascul Pharmacol. 2016 Aug;83:57-65
pubmed: 27084395
Invest Ophthalmol Vis Sci. 1994 Mar;35(3):900-6
pubmed: 8125753
Front Immunol. 2020 Feb 11;11:154
pubmed: 32117292
PLoS One. 2015 Sep 09;10(9):e0137358
pubmed: 26352837
PLoS One. 2018 Mar 27;13(3):e0194603
pubmed: 29584759
Am J Pathol. 1995 Sep;147(3):642-53
pubmed: 7545873
Forensic Sci Int. 2004 Dec 2;146 Suppl:S19-23
pubmed: 15639573
Lab Invest. 1998 Jan;78(1):109-16
pubmed: 9461127
Middle East Afr J Ophthalmol. 2012 Jan;19(1):70-4
pubmed: 22346117
Transl Vis Sci Technol. 2020 Sep 02;9(10):3
pubmed: 32953243
Am J Ophthalmol. 1992 Dec 15;114(6):731-6
pubmed: 1463043
Br J Ophthalmol. 2015 Jul;99(7):960-6
pubmed: 25631486
Vision Res. 2017 Oct;139:221-227
pubmed: 28993218
Int J Retina Vitreous. 2020 Jun 8;6:24
pubmed: 32523777
Eye (Lond). 1992;6 ( Pt 6):553-5
pubmed: 1289129
Jpn J Ophthalmol. 2002 Jul-Aug;46(4):406-12
pubmed: 12225819
FASEB J. 2004 Sep;18(12):1450-2
pubmed: 15231732
J Proteome Res. 2015 Dec 4;14(12):5131-43
pubmed: 26490944
Diabetologia. 2007 Feb;50(2):461-70
pubmed: 17187248
Eye (Lond). 2008 Feb;22(2):223-8
pubmed: 17001327
Diabetologia. 2005 Nov;48(11):2422-7
pubmed: 16193288
Biochem Biophys Res Commun. 2011 Nov 11;415(1):163-7
pubmed: 22027148
Indian J Ophthalmol. 2015 Jan;63(1):33-6
pubmed: 25686060
J Diabetes Complications. 2014 May-Jun;28(3):419-25
pubmed: 24630762
Graefes Arch Clin Exp Ophthalmol. 1993 May;231(5):257-60
pubmed: 8319914
Curr Mol Med. 2017 Dec 7;17(4):280-286
pubmed: 29110608
PLoS One. 2015 May 15;10(5):e0125150
pubmed: 25978536
J Proteome Res. 2013 Mar 1;12(3):1078-89
pubmed: 23368427
Diabetologia. 1997 Sep;40(9):1107-9
pubmed: 9300249
Electrophoresis. 1994 Jul;15(7):936-40
pubmed: 7813399
Int J Mol Sci. 2018 Jun 20;19(6):
pubmed: 29925789
Nippon Ganka Gakkai Zasshi. 2000 Oct;104(10):711-6
pubmed: 11081306
Arch Ophthalmol. 1998 Jun;116(6):738-41
pubmed: 9639441
Mol Vis. 2020 Jun 26;26:472-482
pubmed: 32606566
Cell. 1986 Jul 18;46(2):155-69
pubmed: 3013421
Am J Ophthalmol. 2004 Apr;137(4):668-74
pubmed: 15059706
Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):39
pubmed: 32965482
Acta Ophthalmol. 2019 Dec 12;:
pubmed: 31833198
Acta Diabetol. 2019 Jul;56(7):797-805
pubmed: 30911832
Eye (Lond). 2018 Apr;32(4):820-829
pubmed: 29303154
Prog Retin Eye Res. 2021 Jan 8;:100940
pubmed: 33429059
Int J Biomed Sci. 2007 Mar;3(1):31-7
pubmed: 23675018
J Pharmacol Exp Ther. 2014 Mar;348(3):442-51
pubmed: 24403517
Eye (Lond). 1996;10 ( Pt 6):664-70
pubmed: 9091361
J Clin Invest. 2020 Jul 1;130(7):3833-3847
pubmed: 32343678
Biorheology. 1994 Jul-Aug;31(4):339-51
pubmed: 7981434
Prog Retin Eye Res. 2013 May;34:19-48
pubmed: 23416119
Glia. 2003 Apr 15;42(2):139-48
pubmed: 12655598
Exp Eye Res. 2006 Aug;83(2):401-7
pubmed: 16643893
Lancet Diabetes Endocrinol. 2019 Feb;7(2):140-149
pubmed: 30005958
Oncogene. 2001 Mar 22;20(12):1403-13
pubmed: 11313884
Prog Retin Eye Res. 2000 May;19(3):323-44
pubmed: 10749380
Cytokine. 2010 Mar;49(3):269-74
pubmed: 20015663
J Clin Invest. 1989 May;83(5):1661-6
pubmed: 2708527
Graefes Arch Clin Exp Ophthalmol. 2013 Jan;251(1):15-7
pubmed: 22527328
Diabetes. 2015 Jan;64(1):200-12
pubmed: 25187372
J Exp Med. 1986 May 1;163(5):1037-50
pubmed: 2871125
Mol Vis. 2008 Mar 27;14:637-43
pubmed: 18385799
Diabetes. 1998 Dec;47(12):1953-9
pubmed: 9836530
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6020-4
pubmed: 2888109
Am J Ophthalmol. 2011 Sep;152(3):406-412.e3
pubmed: 21723532
Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8076-85
pubmed: 23139271
Exp Eye Res. 2006 May;82(5):798-806
pubmed: 16324700
J Diabetes Complications. 2001 Sep-Oct;15(5):257-9
pubmed: 11522500
Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2953-5
pubmed: 19060271
Curr Eye Res. 1999 Jun;18(6):490-9
pubmed: 10435836
Ophthalmology. 2009 Jan;116(1):73-9
pubmed: 19118698
Retina. 1999;19(5):383-9
pubmed: 10546932
Diabetes. 1995 Aug;44(8):968-83
pubmed: 7622004
Int J Mol Sci. 2020 Oct 09;21(20):
pubmed: 33050335
Jpn J Ophthalmol. 2011 May;55(3):256-263
pubmed: 21538000
Invest Ophthalmol Vis Sci. 2012 Aug 27;53(9):5906-11
pubmed: 22871833
Am J Ophthalmol. 2001 Sep;132(3):378-82
pubmed: 11530051
Retina. 2014 Jan;34(1):165-71
pubmed: 23851630
Retina. 2010 Feb;30(2):345-52
pubmed: 20175275
Exp Eye Res. 2005 Aug;81(2):176-82
pubmed: 16080911
Biochem Biophys Res Commun. 2012 Aug 31;425(3):540-7
pubmed: 22925671
Curr Eye Res. 2016 Dec;41(12):1590-1600
pubmed: 27261371
Surv Ophthalmol. 2002 Dec;47 Suppl 2:S253-62
pubmed: 12507627
Proteomics Clin Appl. 2008 Sep;2(9):1265-1280
pubmed: 19081814
Am J Ophthalmol. 2009 Dec;148(6):883-9
pubmed: 19837381
Curr Eye Res. 2009 Feb;34(2):152-61
pubmed: 19219687
PLoS One. 2008 Jul 16;3(7):e2675
pubmed: 18628999
Eye (Lond). 2006 Dec;20(12):1366-9
pubmed: 16284605
Cloning Stem Cells. 2002;4(4):339-51
pubmed: 12626097
Ophthalmology. 1980 Feb;87(2):122-8
pubmed: 7383541
Ocul Immunol Inflamm. 2018;26(2):273-279
pubmed: 27537610
Arch Ophthalmol. 1990 Jun;108(6):869-72
pubmed: 1693499
Jpn J Ophthalmol. 2001 Jan-Feb;45(1):40-5
pubmed: 11163044
PLoS One. 2009 Dec 04;4(12):e8158
pubmed: 19997642
Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2759-67
pubmed: 8977492
Surv Ophthalmol. 2010 Mar-Apr;55(2):108-33
pubmed: 20159228
J Int Med Res. 2016 Dec;44(6):1403-1413
pubmed: 27885039
Br J Ophthalmol. 1997 Mar;81(3):228-33
pubmed: 9135388
Proteome Sci. 2012 Mar 05;10(1):15
pubmed: 22390717
J Proteome Res. 2008 Jun;7(6):2516-25
pubmed: 18433156
Diabet Med. 2005 Jun;22(6):719-22
pubmed: 15910622
Am J Pathol. 1998 Jun;152(6):1453-62
pubmed: 9626050
Am J Health Syst Pharm. 2008 Aug 1;65(15):1413-8
pubmed: 18653811
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):4930-8
pubmed: 17962441
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
J Clin Invest. 1992 Jan;89(1):244-53
pubmed: 1729274
Int Ophthalmol. 2018 Apr;38(2):607-615
pubmed: 28299499
Ophthalmic Res. 2013;49(2):108-14
pubmed: 23257933
Int J Ophthalmol. 2020 Sep 18;13(9):1477-1483
pubmed: 32953589
Arch Ophthalmol. 2004 Dec;122(12):1801-7
pubmed: 15596583
Int Ophthalmol Clin. 1973 Fall;13(3):169-87
pubmed: 4204768
Mol Vis. 2011;17:1829-38
pubmed: 21850157
J Clin Invest. 2005 Jan;115(1):86-93
pubmed: 15630447
Diabetes. 2007 Jan;56(1):231-8
pubmed: 17192487
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):2955-62
pubmed: 27273593
Ger J Ophthalmol. 1995 Sep;4(5):269-74
pubmed: 7496336
Diabetes. 2010 Jul;59(7):1780-8
pubmed: 20424229
Exp Eye Res. 2020 Nov;200:108221
pubmed: 32919990
Am J Ophthalmol. 1997 May;123(5):599-606
pubmed: 9152065
Mediators Inflamm. 2013;2013:935301
pubmed: 23365490
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):978-985
pubmed: 29450537
J Biol Chem. 1996 Jan 12;271(2):736-41
pubmed: 8557680
Lab Invest. 2006 Feb;86(2):106-15
pubmed: 16341020
J Biol Chem. 1983 Jun 10;258(11):7155-60
pubmed: 6602130
Exp Eye Res. 2002 Apr;74(4):523-35
pubmed: 12076096
J Biol Chem. 1999 Aug 13;274(33):23463-7
pubmed: 10438525
Br J Ophthalmol. 2002 Mar;86(3):311-5
pubmed: 11864890
Cytokine Growth Factor Rev. 2018 Feb;39:102-115
pubmed: 29248329
Science. 1992 Dec 11;258(5089):1798-801
pubmed: 1281554
Acta Ophthalmol. 2011 May;89(3):248-54
pubmed: 19799585
Ophthalmology. 2013 Jan;120(1):106-14
pubmed: 23031671
Br J Ophthalmol. 2015 May;99(5):629-34
pubmed: 25355804
Retina. 2010 Feb;30(2):339-44
pubmed: 20142713
Retina. 2014 Apr;34(4):741-8
pubmed: 23975003
Arch Ophthalmol. 1991 Jul;109(7):1005-11
pubmed: 2064554
Ophthalmology. 2006 Feb;113(2):294-301
pubmed: 16406543
Graefes Arch Clin Exp Ophthalmol. 2014 Aug;252(8):1229-34
pubmed: 24531563
Acta Ophthalmol. 2013 Aug;91(5):445-52
pubmed: 22520269
Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1097-106
pubmed: 9620068
Adv Clin Exp Med. 2020 Apr;29(4):449-452
pubmed: 32343888
Exp Cell Res. 1992 Feb;198(2):237-49
pubmed: 1729132
Diabetes. 2007 Jan;56(1):224-30
pubmed: 17192486
Exp Eye Res. 2001 Nov;73(5):681-92
pubmed: 11747368
Ophthalmology. 2005 May;112(5):806-16
pubmed: 15878060
Curr Eye Res. 2012 May;37(5):416-20
pubmed: 22409294
Curr Eye Res. 1995 Nov;14(11):1045-53
pubmed: 8585935
N Engl J Med. 1994 Dec 1;331(22):1480-7
pubmed: 7526212
Invest Ophthalmol Vis Sci. 1989 Aug;30(8):1867-71
pubmed: 2759801
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8239-47
pubmed: 26720478
Annu Rev Immunol. 2014;32:433-59
pubmed: 24499275
J Lipid Res. 2015 Mar;56(3):599-611
pubmed: 25598081
Methods Mol Biol. 2019;1996:325-331
pubmed: 31127565
Am J Ophthalmol. 1994 Oct 15;118(4):445-50
pubmed: 7943121
Forensic Sci Int. 2013 Mar 10;226(1-3):160-7
pubmed: 23357227
PLoS One. 2014 Oct 13;9(10):e107551
pubmed: 25310689
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6523-30
pubmed: 26447988
Retina. 2008 Jun;28(6):817-24
pubmed: 18536597
Can J Ophthalmol. 2006 Dec;41(6):747-52
pubmed: 17224958
J Cell Commun Signal. 2019 Dec;13(4):451-462
pubmed: 30607767
Science. 1999 Jul 9;285(5425):245-8
pubmed: 10398599
Invest Ophthalmol Vis Sci. 1994 Aug;35(9):3393-400
pubmed: 8056513
Retina. 2014 Oct;34(10):2003-9
pubmed: 24743641
Retina. 2001;21(1):28-33
pubmed: 11217926
Genes Dev. 2008 May 15;22(10):1276-312
pubmed: 18483217
FASEB J. 2021 Jan;35(1):e21152
pubmed: 33151576
Diabetes. 1997 Sep;46(9):1473-80
pubmed: 9287049
Horm Res. 2000;53(2):53-67
pubmed: 10971090

Auteurs

Siva S R Iyer (SSR)

Department of Ophthalmology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
ORCID: 0000-0002-3442-2311

Mollie K Lagrew (MK)

Department of Ophthalmology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

Stephanie M Tillit (SM)

Department of Ophthalmology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
ORCID: 0000-0002-9420-6047

Ramak Roohipourmoallai (R)

Department of Ophthalmology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

Samuel Korntner (S)

Department of Ophthalmology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
ORCID: 0000-0003-1589-9752

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Humeur aqueuse › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Maladies endocriniennes › Diabète › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Angiopathies diabétiques › Rétinopathie diabétique › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › The Vitreous Ecosystem in Diabetic...
questionsmedicales.fr › Organes des sens › Oeil › Segment postérieur de l'oeil › Corps vitré › The Vitreous Ecosystem in Diabetic...