SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo'.
Antibodies, Viral
/ immunology
COVID-19
/ diagnosis
COVID-19 Nucleic Acid Testing
COVID-19 Testing
/ methods
Contact Tracing
Female
Humans
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Italy
/ epidemiology
Male
Nucleocapsid
SARS-CoV-2
/ immunology
Seroepidemiologic Studies
Serologic Tests
/ methods
Spike Glycoprotein, Coronavirus
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 07 2021
19 07 2021
Historique:
received:
03
03
2021
accepted:
21
06
2021
entrez:
20
7
2021
pubmed:
21
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
In February and March 2020, two mass swab testing campaigns were conducted in Vo', Italy. In May 2020, we tested 86% of the Vo' population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8-4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7-100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0-28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2-36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.
Identifiants
pubmed: 34282139
doi: 10.1038/s41467-021-24622-7
pii: 10.1038/s41467-021-24622-7
pmc: PMC8289856
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Spike Glycoprotein, Coronavirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4383Subventions
Organisme : Wellcome Trust
ID : 203851/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19012
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213494/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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