Colorectal cancer after bariatric surgery (Cric-Abs 2020): Sicob (Italian society of obesity surgery) endorsed national survey.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
25
01
2021
accepted:
06
07
2021
revised:
28
06
2021
pubmed:
21
7
2021
medline:
3
2
2022
entrez:
20
7
2021
Statut:
ppublish
Résumé
The published colorectal cancer (CRC) outcomes after bariatric surgery (BS) are conflicting, with some anecdotal studies reporting increased risks. The present nationwide survey CRIC-ABS 2020 (Colo-Rectal Cancer Incidence-After Bariatric Surgery-2020), endorsed by the Italian Society of Obesity Surgery (SICOB), aims to report its incidence in Italy after BS, comparing the two commonest laparoscopic procedures-Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (GBP). Two online questionnaires-first having 11 questions on SG/GBP frequency with a follow-up of 5-10 years, and the second containing 15 questions on CRC incidence and management, were administered to 53 referral bariatric, high volume centers. A standardized incidence ratio (SIR-a ratio of the observed number of cases to the expected number) with 95% confidence intervals (CI) was calculated along with CRC incidence risk computation for baseline characteristics. Data for 20,571 patients from 34 (63%) centers between 2010 and 2015 were collected, of which 14,431 had SG (70%) and 6140 GBP (30%). 22 patients (0.10%, mean age = 53 ± 12 years, 13 males), SG: 12 and GBP: 10, developed CRC after 4.3 ± 2.3 years. Overall incidence was higher among males for both groups (SG: 0.15% vs 0.05%; GBP: 0.35% vs 0.09%) and the GBP cohort having slightly older patients. The right colon was most affected (n = 13) and SIR categorized/sex had fewer values < 1, except for GBP males (SIR = 1.07). Low CRC incidence after BS at 10 years (0.10%), and no difference between procedures was seen, suggesting that BS does not trigger the neoplasm development.
Sections du résumé
BACKGROUND
The published colorectal cancer (CRC) outcomes after bariatric surgery (BS) are conflicting, with some anecdotal studies reporting increased risks. The present nationwide survey CRIC-ABS 2020 (Colo-Rectal Cancer Incidence-After Bariatric Surgery-2020), endorsed by the Italian Society of Obesity Surgery (SICOB), aims to report its incidence in Italy after BS, comparing the two commonest laparoscopic procedures-Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (GBP).
METHODS
Two online questionnaires-first having 11 questions on SG/GBP frequency with a follow-up of 5-10 years, and the second containing 15 questions on CRC incidence and management, were administered to 53 referral bariatric, high volume centers. A standardized incidence ratio (SIR-a ratio of the observed number of cases to the expected number) with 95% confidence intervals (CI) was calculated along with CRC incidence risk computation for baseline characteristics.
RESULTS
Data for 20,571 patients from 34 (63%) centers between 2010 and 2015 were collected, of which 14,431 had SG (70%) and 6140 GBP (30%). 22 patients (0.10%, mean age = 53 ± 12 years, 13 males), SG: 12 and GBP: 10, developed CRC after 4.3 ± 2.3 years. Overall incidence was higher among males for both groups (SG: 0.15% vs 0.05%; GBP: 0.35% vs 0.09%) and the GBP cohort having slightly older patients. The right colon was most affected (n = 13) and SIR categorized/sex had fewer values < 1, except for GBP males (SIR = 1.07).
CONCLUSION
Low CRC incidence after BS at 10 years (0.10%), and no difference between procedures was seen, suggesting that BS does not trigger the neoplasm development.
Identifiants
pubmed: 34282268
doi: 10.1038/s41366-021-00910-6
pii: 10.1038/s41366-021-00910-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2527-2531Investigateurs
Luigi Angrisani
(L)
Alessandro Balani
(A)
Fabrizio Bellini
(F)
Vincenzo Borrelli
(V)
Marcello Boni
(M)
Fabio Cesare Campanile
(FC)
Giovanni Cesana
(G)
Franco Ciampaglia
(F)
Maurizio De Luca
(M)
Marco Antonio De Paoli
(MA)
Mirto Foletto
(M)
Diego Foschi
(D)
Paolo Gentileschi
(P)
Cristiano Giardiello
(C)
Alessandro Giovanelli
(A)
Mario Godina
(M)
Ezio Lattuada
(E)
Marcello Lucchese
(M)
Emilio Manno
(E)
Giuseppe Maria Marinari
(GM)
Gennaro Martines
(G)
Bernardo Marzano
(B)
Paolo Millo
(P)
Roberto Moroni
(R)
Mario Musella
(M)
Giuseppe Navarra
(G)
Stefano Olmi
(S)
Natale Pellicanò
(N)
Andrea Peri
(A)
Nicola Perrotta
(N)
Vincenzo Pilone
(V)
Luigi Piazza
(L)
Marco Raffaelli
(M)
Giuliano Sarro
(G)
Angelo Michele Schettino
(AM)
Socci Carlo
(S)
Giuseppe Vuolo
(G)
Marco Antonio Zappa
(MA)
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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