Syndecan-4 in Tumor Cell Motility.
EMT
actin
calcium
cancer
cell polarity
centrosome
extracellular matrix
metastasis
migration
proteoglycan
syndecan-4
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Jul 2021
01 Jul 2021
Historique:
received:
30
04
2021
revised:
25
06
2021
accepted:
27
06
2021
entrez:
20
7
2021
pubmed:
21
7
2021
medline:
21
7
2021
Statut:
epublish
Résumé
Syndecan-4 (SDC4) is a ubiquitously expressed, transmembrane proteoglycan bearing heparan sulfate chains. SDC4 is involved in numerous inside-out and outside-in signaling processes, such as binding and sequestration of growth factors and extracellular matrix components, regulation of the activity of the small GTPase Rac1, protein kinase C-alpha, the level of intracellular calcium, or the phosphorylation of focal adhesion kinase. The ability of this proteoglycan to link the extracellular matrix and actin cytoskeleton enables SDC4 to contribute to biological functions like cell adhesion and migration, cell proliferation, cytokinesis, cellular polarity, or mechanotransduction. The multiple roles of SDC4 in tumor pathogenesis and progression has already been demonstrated; therefore, the expression and signaling of SDC4 was investigated in several tumor types. SDC4 influences tumor progression by regulating cell proliferation as well as cell migration by affecting cell-matrix adhesion and several signaling pathways. Here, we summarize the general role of SDC4 in cell migration and tumor cell motility.
Identifiants
pubmed: 34282767
pii: cancers13133322
doi: 10.3390/cancers13133322
pmc: PMC8268284
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Research, Development and Innovation Office of Hungary
ID : GINOP-2.3.2-15-2016-00040 (MYOTeam)
Organisme : National Research, Development and Innovation Office of Hungary
ID : NKFI FK 134684
Organisme : National Research, Development and Innovation Office of Hungary
ID : NKFI K 132446
Organisme : New National Excellence Program of the Ministry for Innovation and Technology Sciences
ID : UNKP-20-5-SZTE-162
Organisme : the János Bolyai Research Scholarship of the Hungarian Academy of Sciences
Organisme : Szeged Scientists Academy under the sponsorship of the Hungarian Ministry of Innovation and Technology
ID : FEIF/433-4/2020-ITM_SZERZ
Organisme : National Research, Development and Innovation Office of Hungary
ID : EFOP 3.6.3 VEKOP-16-2017 00009
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