The Hitchhiker's guide to glycoproteomics.
glycobiology
glycomics
glycoproteomics
mass spectrometry
multi-omics
proteomics
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
27 08 2021
27 08 2021
Historique:
received:
09
04
2021
revised:
03
06
2021
accepted:
23
06
2021
pubmed:
21
7
2021
medline:
16
2
2022
entrez:
20
7
2021
Statut:
ppublish
Résumé
Protein glycosylation is one of the most common post-translational modifications that are essential for cell function across all domains of life. Changes in glycosylation are considered a hallmark of many diseases, thus making glycoproteins important diagnostic and prognostic biomarker candidates and therapeutic targets. Glycoproteomics, the study of glycans and their carrier proteins in a system-wide context, is becoming a powerful tool in glycobiology that enables the functional analysis of protein glycosylation. This 'Hitchhiker's guide to glycoproteomics' is intended as a starting point for anyone who wants to explore the emerging world of glycoproteomics. The review moves from the techniques that have been developed for the characterisation of single glycoproteins to technologies that may be used for a successful complex glycoproteome characterisation. Examples of the variety of approaches, methodologies, and technologies currently used in the field are given. This review introduces the common strategies to capture glycoprotein-specific and system-wide glycoproteome data from tissues, body fluids, or cells, and a perspective on how integration into a multi-omics workflow enables a deep identification and characterisation of glycoproteins - a class of biomolecules essential in regulating cell function.
Identifiants
pubmed: 34282822
pii: 229276
doi: 10.1042/BST20200879
pmc: PMC8421054
doi:
Substances chimiques
Glycoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1643-1662Informations de copyright
© 2021 The Author(s).
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