Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common-A Metagenomic Comparison with Healthy Subjects.

Peptostreptococcus Solobacterium spp. Streptococcus colorectal cancer microbiota oral bacteria

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
02 Jul 2021
Historique:
received: 18 05 2021
revised: 23 06 2021
accepted: 25 06 2021
entrez: 20 7 2021
pubmed: 21 7 2021
medline: 21 7 2021
Statut: epublish

Résumé

Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as

Identifiants

pubmed: 34283063
pii: cancers13133332
doi: 10.3390/cancers13133332
pmc: PMC8268706
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 19K10361,15H05045

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Auteurs

Yoshinori Uchino (Y)

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

Yuichi Goto (Y)

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

Yusuke Konishi (Y)

Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan.

Kan Tanabe (K)

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.

Hiroko Toda (H)

Breast Surgery, Fujita Health University Hospital, 1-98, Dengakubo, Kutsukake, Toyoake, Aichi 470-1192, Japan.

Masumi Wada (M)

Department of Digestive Surgery, Imakiire General Hospital, 43-25, Korai, Kagoshima 890-0051, Japan.

Yoshiaki Kita (Y)

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.

Mahiro Beppu (M)

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

Shinichiro Mori (S)

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.

Hiroshi Hijioka (H)

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

Takao Otsuka (T)

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.

Shoji Natsugoe (S)

Kajikionsen Hospital, 4714, Kida, Kajiki, Aira, Kagoshima 899-5241, Japan.

Eiji Hara (E)

Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan.

Tsuyoshi Sugiura (T)

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

Classifications MeSH