Ceramides in Skin Health and Disease: An Update.
Journal
American journal of clinical dermatology
ISSN: 1179-1888
Titre abrégé: Am J Clin Dermatol
Pays: New Zealand
ID NLM: 100895290
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
accepted:
23
06
2021
pubmed:
21
7
2021
medline:
19
2
2022
entrez:
20
7
2021
Statut:
ppublish
Résumé
Ceramides are a class of sphingolipid that is the backbone structure for all sphingolipids, such as glycosphingolipids and phosphosphingolipids. While being a minor constituent of cellular membranes, ceramides are the major lipid component (along with cholesterol, free fatty acid, and other minor components) of the intercellular spaces of stratum corneum that forms the epidermal permeability barrier. These stratum corneum ceramides consist of unique heterogenous molecular species that have only been identified in terrestrial mammals. Alterations of ceramide molecular profiles are characterized in skin diseases associated with compromised permeability barrier functions, such as atopic dermatitis, psoriasis and xerosis. In addition, hereditary abnormalities of some ichthyoses are associated with an epidermal unique ceramide species, omega-O-acylceramide. Ceramides also serve as lipid modulators to regulate cellular functions, including cell cycle arrest, differentiation, and apoptosis, and it has been demonstrated that changes in ceramide metabolism also cause certain diseases. In addition, ceramide metabolites, sphingoid bases, sphingoid base-1-phosphate and ceramide-1-phosphate are also lipid mediators that regulate cellular functions. In this review article, we describe diverse physiological and pathological roles of ceramides and their metabolites in epidermal permeability barrier function, epidermal cell proliferation and differentiation, immunity, and cutaneous diseases. Finally, we summarize the utilization of ceramides as therapy to treat cutaneous disease.
Identifiants
pubmed: 34283373
doi: 10.1007/s40257-021-00619-2
pii: 10.1007/s40257-021-00619-2
doi:
Substances chimiques
Ceramides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
853-866Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR062025
Pays : United States
Organisme : National Research Foundation of Korea
ID : 2018R1D1A1B7050504
Organisme : Ministry of Trade, Industry and Energy
ID : P0014701
Organisme : NIAMS NIH HHS
ID : R01 AR062025
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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