Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment.
Alkaloids
Traditional Chinese Medicine
Tumor development
Tumor microenvironment
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
20 Jul 2021
20 Jul 2021
Historique:
received:
28
02
2021
accepted:
08
07
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
22
7
2021
Statut:
epublish
Résumé
Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tumor growth and progression are strongly dependent on its surrounding tumor microenvironment, because the optimal conditions originated from stromal elements are required for cancer cell proliferation, invasion, metastasis and drug resistance. The tumor microenvironment is an environment rich in immune/inflammatory cells and accompanied by a continuous, gradient of hypoxia and pH. Overcoming immunosuppressive environment and boosting anti-tumor immunity may be the key to the prevention and treatment of cancer. Most traditional Chinese medicine have been proved to have good anti-tumor activity, and they have the advantages of better therapeutic effect and few side effects in the treatment of malignant tumors. An increasing number of studies are giving evidence that alkaloids extracted from traditional Chinese medicine possess a significant anticancer efficiency via regulating a variety of tumor-related genes, pathways and other mechanisms. This paper reviews the anti-tumor effect of alkaloids targeting tumor microenvironment, and further reveals its anti-tumor mechanism through the effects of alkaloids on different components in tumor microenvironment.
Identifiants
pubmed: 34284780
doi: 10.1186/s12935-021-02085-6
pii: 10.1186/s12935-021-02085-6
pmc: PMC8290600
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
386Subventions
Organisme : National Natural Science Foundation of China
ID : Nos. 81873089
Organisme : National Natural Science Foundation of China
ID : Nos.81603253
Organisme : National Natural Science Foundation of China
ID : No. 81973570
Organisme : Important Drug Development Fund, Ministry of Science and Technology of China
ID : 2018ZX09735-002
Organisme : Important Drug Development Fund, Ministry of Science and Technology of China
ID : No. 2018ZX092011
Organisme : Science and Technology Program of Tianjin
ID : No.20ZYJDJC00070
Informations de copyright
© 2021. The Author(s).
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