Bidirectional Regulatory Cross-Talk between Cell Context and Genomic Aberrations Shapes Breast Tumorigenesis.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
05
03
2021
revised:
02
06
2021
accepted:
16
07
2021
pubmed:
22
7
2021
medline:
23
3
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Breast cancers are classified into five intrinsic subtypes and 10 integrative clusters based on gene expression patterns and genomic aberrations, respectively. Although the cell-of-origin, adaptive plasticity, and genomic aberrations shape dynamic transcriptomic landscape during cancer progression, how interplay between these three core elements governs obligatory steps for a productive cancer progression is unknown. Here, we used genetic ancestry-mapped immortalized breast epithelial cell lines generated from breast biopsies of healthy women that share gene expression profiles of luminal A, normal-like, and basal-like intrinsic subtypes of breast cancers and breast cancer relevant oncogenes to develop breast cancer progression model. Using flow cytometry, mammosphere growth, signaling pathway, DNA damage response, and
Identifiants
pubmed: 34285086
pii: 1541-7786.MCR-21-0163
doi: 10.1158/1541-7786.MCR-21-0163
pmc: PMC8568628
mid: NIHMS1728184
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1802-1817Subventions
Organisme : NCI NIH HHS
ID : P30 CA082709
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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