Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer.
Carrier Proteins
/ genetics
Cell Line, Tumor
Cell Proliferation
GTP-Binding Proteins
/ chemistry
Gene Amplification
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genomics
Humans
Methyltransferases
/ chemistry
Models, Molecular
Neoplasm Grading
Neoplasms
/ genetics
Prognosis
Protein Binding
Protein Conformation
Proteomics
Survival Analysis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 07 2021
20 07 2021
Historique:
received:
25
01
2021
accepted:
04
06
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Human methyltransferase-like (METTL) proteins transfer methyl groups to nucleic acids, proteins, lipids, and other small molecules, subsequently playing important roles in various cellular processes. In this study, we performed integrated genomic, transcriptomic, proteomic, and clinicopathological analyses of 34 METTLs in a large cohort of primary tumor and cell line data. We identified a subset of METTL genes, notably METTL1, METTL7B, and NTMT1, with high frequencies of genomic amplification and/or up-regulation at both the mRNA and protein levels in a spectrum of human cancers. Higher METTL1 expression was associated with high-grade tumors and poor disease prognosis. Loss-of-function analysis in tumor cell lines indicated the biological importance of METTL1, an m
Identifiants
pubmed: 34285249
doi: 10.1038/s41598-021-94019-5
pii: 10.1038/s41598-021-94019-5
pmc: PMC8292347
doi:
Substances chimiques
Carrier Proteins
0
METTL7B protein, human
0
WDR4 protein, human
0
METTL1 protein, human
EC 2.1.1.-
Methyltransferases
EC 2.1.1.-
NTMT1 protein, human
EC 2.1.1.-
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
14784Subventions
Organisme : NCI NIH HHS
ID : R21 CA256423
Pays : United States
Informations de copyright
© 2021. The Author(s).
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