Repurposing colchicine's journey in view of drug-to-drug interactions. A review.
ACS, acute coronary syndrome
CAD, coronary artery disease
COVID-19, coronavirus disease - 19
Colchicine
DOACs, direct oral anticoagulants
History
Inflammation
Lp-PLA2, Lipoprotein-associated phospholipase A2
NLRP3, NOD-, LRR- and pyrin domain-containing protein 3
Pharmacokinetics
ROCK, Rho-associated protein kinase
Repurposing
Safety
eGFR, estimated glomerular filtration rate
Journal
Toxicology reports
ISSN: 2214-7500
Titre abrégé: Toxicol Rep
Pays: Ireland
ID NLM: 101630272
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
03
2021
revised:
10
05
2021
accepted:
08
07
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
22
7
2021
Statut:
epublish
Résumé
Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.
Identifiants
pubmed: 34285885
doi: 10.1016/j.toxrep.2021.07.009
pii: S2214-7500(21)00136-0
pmc: PMC8280530
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1389-1393Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2021 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors report no declarations of interest.
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