Topographically guided hierarchical mineralization.

Bone Crystallization Dental enamel Elastin-like recombinamer Fluorapatite Hierarchical mineralization Protein-based biomineralization Surface topographies

Journal

Materials today. Bio
ISSN: 2590-0064
Titre abrégé: Mater Today Bio
Pays: England
ID NLM: 101757228

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 23 01 2021
revised: 29 05 2021
accepted: 02 06 2021
entrez: 21 7 2021
pubmed: 22 7 2021
medline: 22 7 2021
Statut: epublish

Résumé

Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topographies to grow spatially guided mineralized structures. We reveal how well-defined geometrical spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the microscale and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct the anisotropic growth of such structures would have important implications in the design of biomineralizing synthetic materials to repair or regenerate hard tissues.

Identifiants

DOI: 10.1016/j.mtbio.2021.100119 PMID: 34286238 PMC: PMC8273417
pubmed: 34286238
doi: 10.1016/j.mtbio.2021.100119
pii: S2590-0064(21)00027-2
pmc: PMC8273417
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100119

Subventions

Organisme : Medical Research Council
ID : MR/R015651/1
Pays : United Kingdom

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7670-7675
pubmed: 29967143
Nat Protoc. 2011 Jun;6(6):845-58
pubmed: 21637203
Nat Mater. 2012 Jul 01;11(8):724-33
pubmed: 22751179
FEBS Lett. 1986 Oct 6;206(2):262-6
pubmed: 3019771
Acta Biomater. 2013 Jul;9(7):7289-97
pubmed: 23571002
Biomaterials. 2010 Dec;31(35):9202-11
pubmed: 20869764
ACS Omega. 2018 Mar 31;3(3):2546-2557
pubmed: 29623301
Adv Mater. 2020 Aug;32(31):e2002080
pubmed: 32583928
Sci Rep. 2017 Jan 12;7:40701
pubmed: 28079165
Front Physiol. 2017 Jun 08;8:368
pubmed: 28642715
ACS Appl Mater Interfaces. 2014 Jan 8;6(1):410-20
pubmed: 24354267
Arch Oral Biol. 2013 Nov;58(11):1726-34
pubmed: 24112740
Microsc Microanal. 2005 Dec;11(6):516-23
pubmed: 17481330
J Mater Chem B. 2016 Feb 7;4(5):880-886
pubmed: 32263160
Adv Healthc Mater. 2018 Sep;7(18):e1800178
pubmed: 29943412
Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6582-96
pubmed: 22639420
Nat Commun. 2018 Jun 1;9(1):2145
pubmed: 29858566
Nanoscale. 2010 Oct;2(10):1842-8
pubmed: 20676452
J Dent Res. 1998 Mar;77(3):472-80
pubmed: 9496920
J Tissue Eng Regen Med. 2007 May-Jun;1(3):185-91
pubmed: 18038410
Science. 2013 May 17;340(6134):832-7
pubmed: 23687041
Macromol Biosci. 2007 Feb 12;7(2):152-62
pubmed: 17295402
Biomaterials. 2014 Sep;35(29):8339-47
pubmed: 24996755
Sci Rep. 2016 Mar 24;6:23105
pubmed: 27009419
Cryst Growth Des. 2018 Dec 5;18(12):7391-7400
pubmed: 32280310
Adv Mater. 2020 Aug;32(31):e2001068
pubmed: 32583495
ACS Appl Mater Interfaces. 2017 Feb 22;9(7):5838-5846
pubmed: 28127954
Chem Rev. 2008 Nov;108(11):4754-83
pubmed: 19006400
Chem Rev. 2008 Nov;108(11):4332-432
pubmed: 19006397
Int J Nanomedicine. 2007;2(3):389-406
pubmed: 18019838
Cryst Growth Des. 2006 Jun 1;6(6):1504-1508
pubmed: 19513184
Acta Biomater. 2014 May;10(5):2241-9
pubmed: 24434535
Nat Commun. 2019 Sep 26;10(1):4383
pubmed: 31558712
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14097-102
pubmed: 21825148

Auteurs

X Deng (X)

School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.

A Hasan (A)

School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, NG7 2RD, UK.
Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.

S Elsharkawy (S)

Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK.

E Tejeda-Montes (E)

Mabxience, Insud Pharma, León, Spain.

N V Tarakina (NV)

Max Planck Institute of Colloids and Interfaces, Potsdam-Golm Science Park, Am Mühlenberg 1 OT Golm, Potsdam, 14476, Germany.

G Greco (G)

Laboratory of Bio-Inspired, Bionic, Nano, Meta, Materials & Mechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, 38122, Italy.

E Nikulina (E)

CIC nanoGUNE BRTA, Tolosa Hiribidea, 76, Donostia - San Sebastian, E-20018, Spain.

J M Stormonth-Darling (JM)

James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.

N Convery (N)

James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.

J C Rodriguez-Cabello (JC)

BIOFORGE Group, University of Valladolid, CIBER-BBN, Valladolid, Spain.

A Boyde (A)

Oral Bioengineering, Queen Mary University of London, London, E1 4NS, UK.

N Gadegaard (N)

James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.

N M Pugno (NM)

Laboratory of Bio-Inspired, Bionic, Nano, Meta, Materials & Mechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, 38122, Italy.
School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

M Al-Jawad (M)

School of Dentistry, University of Leeds, Leeds, LS2 9JT, UK.

A Mata (A)

School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, NG7 2RD, UK.
Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.

Classifications MeSH