Porcine Hemagglutinating Encephalomyelitis Virus Triggers Neural Autophagy Independently of ULK1.
Animals
Autophagosomes
/ metabolism
Autophagy
/ physiology
Autophagy-Related Protein-1 Homolog
/ genetics
Beclin-1
/ metabolism
Betacoronavirus 1
/ metabolism
COVID-19
Cell Line
Gene Knockout Techniques
Intracellular Signaling Peptides and Proteins
/ metabolism
Male
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Mice, Inbred BALB C
Neurons
/ metabolism
Phosphorylation
SARS-CoV-2
BECN1
ULK1
autophagosome
autophagy
coronavirus
porcine hemagglutinating encephalomyelitis virus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
pubmed:
22
7
2021
medline:
23
9
2021
entrez:
21
7
2021
Statut:
ppublish
Résumé
Uncoordinated 51-like kinase 1 (ULK1) is a well-characterized initiator of canonical autophagy under basal or pathological conditions. Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus (β-CoV), impairs ULK1 kinase but hijacks autophagy to facilitate viral proliferation. However, the machinery of PHEV-induced autophagy initiation upon ULK1 kinase deficiency remains unclear. Here, the time course of PHEV infection showed a significant accumulation of autophagosomes (APs) in nerve cells
Identifiants
pubmed: 34287052
doi: 10.1128/JVI.00851-21
pmc: PMC8428410
doi:
Substances chimiques
Beclin-1
0
Becn1 protein, mouse
0
Intracellular Signaling Peptides and Proteins
0
Autophagy-Related Protein-1 Homolog
EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Ulk1 protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0085121Subventions
Organisme : Fundamental Research Funds for the Central Universities
Organisme : National Key Research and Development Program of China
ID : 2016YFD0500102
Organisme : Youth Science and Technology Talent Support Project of Jilin Province
ID : QT202015
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31902262
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31872446
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31772704
Références
J Mol Biol. 2020 Apr 3;432(8):2546-2559
pubmed: 32006535
J Mol Biol. 2020 Jan 3;432(1):123-134
pubmed: 31351898
Autophagy. 2013 Feb 1;9(2):124-37
pubmed: 23295650
Cell Death Differ. 2019 Dec;26(12):2810
pubmed: 31073230
Cell Res. 2007 Oct;17(10):839-49
pubmed: 17893711
Nat Cell Biol. 2013 Jul;15(7):727-8
pubmed: 23817237
Cell. 2015 Jun 4;161(6):1306-19
pubmed: 26027738
Ann N Y Acad Sci. 2020 May;1467(1):3-20
pubmed: 31985829
Autophagy. 2011 Nov;7(11):1335-47
pubmed: 21799305
J Virol. 2018 Jul 31;92(16):
pubmed: 29875237
J Biol Chem. 2004 Mar 12;279(11):10136-41
pubmed: 14699140
J Virol. 2017 Jul 12;91(15):
pubmed: 28515304
Mol Biol Cell. 2009 Apr;20(7):1992-2003
pubmed: 19225151
Nat Rev Mol Cell Biol. 2011 Dec 14;13(1):7-12
pubmed: 22166994
J Comp Pathol. 2001 Jul;125(1):8-14
pubmed: 11437511
Cell. 2006 Sep 8;126(5):955-68
pubmed: 16959574
Adv Exp Med Biol. 2019;1206:67-83
pubmed: 31776980
Mol Neurobiol. 2020 Dec;57(12):5299-5306
pubmed: 32876841
Biochem Biophys Res Commun. 2021 Feb 12;540:75-82
pubmed: 33450483
Front Cell Infect Microbiol. 2017 May 03;7:155
pubmed: 28516065
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731
pubmed: 32226290
Mol Cell. 2008 Apr 25;30(2):214-26
pubmed: 18439900
F1000Res. 2020 Mar 26;9:
pubmed: 32266060
Curr Opin Cell Biol. 2010 Apr;22(2):132-9
pubmed: 20056399
Autophagy. 2020 Dec;16(12):2260-2266
pubmed: 32522067
Viruses. 2017 Jul 11;9(7):
pubmed: 28696396
Cell Host Microbe. 2010 Jun 25;7(6):500-8
pubmed: 20542253
J Mol Biol. 2016 May 8;428(9 Pt A):1725-41
pubmed: 27059781
Nature. 2020 Feb;578(7796):605-609
pubmed: 32051584
Nature. 2017 Dec 21;552(7685):368-373
pubmed: 29236692
Autophagy. 2018;14(7):1201-1213
pubmed: 29929428
Autophagy. 2020 Dec;16(12):2131-2139
pubmed: 32964796
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
Front Cell Infect Microbiol. 2017 Feb 28;7:56
pubmed: 28293544
mSphere. 2020 May 6;5(3):
pubmed: 32376700
Protein Cell. 2014 Dec;5(12):912-27
pubmed: 25311841
Nat Cell Biol. 2009 Apr;11(4):385-96
pubmed: 19270696
Autophagy. 2011 Jul;7(7):689-95
pubmed: 21460635
PeerJ. 2016 Sep 15;4:e2443
pubmed: 27672502
Mol Cell Biol. 2012 Jan;32(1):2-11
pubmed: 22025673
Autophagy. 2018;14(4):584-597
pubmed: 29313410
Protein Cell. 2020 Oct;11(10):723-739
pubmed: 32754890
Mol Biol Cell. 2009 Apr;20(7):1981-91
pubmed: 19211835
J Proteome Res. 2009 Nov;8(11):5253-63
pubmed: 19807128
Mol Cell Endocrinol. 2020 May 15;508:110792
pubmed: 32199904