Successful resection of a huge hepatocellular adenoma.
HNF-1α-inactivated type
Hepatocellular adenoma
Liver tumor
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
06
06
2021
accepted:
17
07
2021
pubmed:
22
7
2021
medline:
16
9
2021
entrez:
21
7
2021
Statut:
ppublish
Résumé
Hepatocellular adenoma (HCA) is a rare benign liver tumor that has been reported to occur particularly more often in women who use contraceptives. A 72-year-old woman with no history of using contraceptives presented to our hospital for further examination of a liver tumor. Contrast-enhanced computed tomography and gadoxetic acid-enhanced magnetic resonance imaging revealed a huge solitary hepatic tumor measuring 83 × 76 mm in segments 4, 5, and 8. The differential diagnoses were cholangiocarcinoma and mixed-type hepatocellular carcinoma. Percutaneous needle biopsies were performed twice, and no malignant components were found. Central bi-segmentectomy of the liver was successfully performed. Immunohistochemical staining showed that β-catenin was positive in the membrane of the tumor cells, while fatty acid-binding protein, glutamine synthetase, and amyloid A were negative. These results led to a diagnosis of HCA, hepatocyte nuclear factor-1α-inactivated subtype. The patient's postoperative course was uneventful, and she developed no recurrence for 10 months after surgery. We experienced a rare case of benign HCA. Obtaining a correct preoperative diagnosis is sometimes difficult at the first evaluation. HCA should be considered as a differential diagnosis of liver tumors.
Identifiants
pubmed: 34287778
doi: 10.1007/s12328-021-01486-4
pii: 10.1007/s12328-021-01486-4
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1544-1549Informations de copyright
© 2021. Japanese Society of Gastroenterology.
Références
Rooks JB, Ory HW, Ishak KG, et al. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA. 1979;242:644–8.
doi: 10.1001/jama.1979.03300070040020
Reddy KR, Schiff ER. Approach to a liver mass. Seminars Liver Dis. 1993;13:423–35.
doi: 10.1055/s-2007-1007370
Sasaki M, Nakanuma Y. Overview of hepatocellular adenoma in Japan. Int J Hepatol. 2012;2012:648131.
pubmed: 22973519
pmcid: 3438775
Stoot JH, van der Linden E, Terpstra OT, et al. Life-saving therapy for haemorrhaging liver adenomas using selective arterial embolization. Br J Surg. 2007;94:1249–53.
doi: 10.1002/bjs.5779
Terkivatan T, de Wilt JH, de Man RA, et al. Treatment of ruptured hepatocellular adenoma. Br J Surg. 2001;88:207–9.
doi: 10.1046/j.1365-2168.2001.01648.x
Chuang WY, Chen TC, Hsu HL, et al. Liver cell adenoma with concomitant hepatocellular carcinoma: report of two cases. J Formos Med Assoc. 2002;101:798–802.
pubmed: 12517062
Dokmak S, Paradis V, Vilgrain V, et al. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology. 2009;137:1698–705.
doi: 10.1053/j.gastro.2009.07.061
Micchelli ST, Vivekanandan P, Boitnott JK, et al. Malignant transformation of hepatic adenomas. Mod Pathol. 2008;21:491–7.
doi: 10.1038/modpathol.2008.8
Laurent A, Dokmak S, Nault JC, et al. European experience of 573 liver resections for hepatocellular adenoma: a cross-sectional study by the AFC-HCA-2013 study group. HPB (Oxford). 2016;18:748–55.
doi: 10.1016/j.hpb.2016.06.011
Bioulac-Sage P, Taouji S, Possenti L, et al. Hepatocellular adenoma subtypes: the impact of overweight and obesity. Liver Int. 2012;32:1217–21.
doi: 10.1111/j.1478-3231.2012.02786.x
Dokmak S, Belghiti J. Will weight loss become a future treatment of hepatocellular adenoma in obese patients? Liver Int. 2015;35:2228–32.
doi: 10.1111/liv.12925
Bunchorntavakul C, Bahirwani R, Drazek D, et al. Clinical features and natural history of hepatocellular adenomas: the impact of obesity. Aliment Pharmacol Ther. 2011;34:664–74.
doi: 10.1111/j.1365-2036.2011.04772.x
Katabathina VS, Menias CO, Shanbhogue AK, et al. Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 2011;31:1529–43.
doi: 10.1148/rg.316115527
Mounajjed T. Hepatocellular adenoma and focal nodular hyperplasia. Clin Liver Dis (Hoboken). 2021;17:244–8.
doi: 10.1002/cld.1069
Stoot JH, Coelen RJ, De Jong MC, et al. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB (Oxford). 2010;12:509–22.
doi: 10.1111/j.1477-2574.2010.00222.x
Cho SW, Marsh JW, Steel J, et al. Surgical management of hepatocellular adenoma: take it or leave it? Ann Surg Oncol. 2008;15:2795–803.
doi: 10.1245/s10434-008-0090-0
Kudo M. Malignant transformation of hepatocellular adenoma: how frequently does it happen? Liver Cancer. 2015;4:1–5.
doi: 10.1159/000367727
Kim DH, Kim SU, Nam DH, et al. A case of hepatocellular carcinoma within hepatocellular adenoma in a non-cirrhotic male. Korean J Intern Med. 2009;24:147–52.
doi: 10.3904/kjim.2009.24.2.147
Khaoudy I, Rebibo L, Regimbeau JM. Is bariatric surgery a potential new treatment for large inflammatory hepatocellular adenomas in obese patients? Surg Obes Relat Dis. 2018;14:535–8.
doi: 10.1016/j.soard.2018.01.006
Bioulac-Sage P, Laumonier H, Couchy G, et al. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology. 2009;50:481–9.
doi: 10.1002/hep.22995
Bioulac-Sage P, Balabaud C, Zucman-Rossi J. Subtype classification of hepatocellular adenoma. Dig Surg. 2010;27:39–45.
doi: 10.1159/000268406
Laumonier H, Bioulac-Sage P, Laurent C, et al. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. 2008;48:808–18.
doi: 10.1002/hep.22417
Bioulac-Sage P, Cubel G, Taouji S, et al. Immunohistochemical markers on needle biopsies are helpful for the diagnosis of focal nodular hyperplasia and hepatocellular adenoma subtypes. Am J Surg Pathol. 2012;36:1691–9.
doi: 10.1097/PAS.0b013e3182653ece