White blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study.
COVID‐19
D‐dimer
SARS‐CoV‐2
ferritin
predictive factor
pulmonary embolism
white blood count
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
23
04
2021
received:
03
04
2021
accepted:
26
04
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
31
7
2021
Statut:
ppublish
Résumé
A high prevalence of pulmonary embolism (PE) has been described during COVID-19. Our aim was to identify predictive factors of PE in non-ICU hospitalized COVID-19 patients. Data and outcomes were collected upon admission during a French multicenter retrospective study, including patients hospitalized for COVID-19, with a CT pulmonary angiography (CTPA) performed in the emergency department for suspected PE. Predictive factors significantly associated with PE were identified through a multivariate regression model. A total of 88 patients (median [IQR] age of 68 years [60-78]) were analyzed. Based on CTPA, 47 (53.4%) patients were diagnosed with PE, and 41 were not. D-dimer ≥3000 ng/mL (OR 8.2 [95% CI] 1.3-74.2, sensitivity (Se) 0.84, specificity (Sp) 0.78, P = .03), white blood count (WBC) ≥12.0 G/L (29.5 [2.3-1221.2], Se 0.47, Sp 0.92, P = .02), and ferritin ≥480 µg/L (17.0 [1.7-553.3], Se 0.96, Sp 0.44, P = .03) were independently associated with the PE diagnosis. The presence of the double criterion D-dimer ≥3000 ng/mL and WBC ≥12.0 G/L was greatly associated with PE (OR 21.4 [4.0-397.9], P = .004). The white blood count, the D-dimer and ferritin levels could be used as an indication for CTPA to confirm PE on admission in non-ICU COVID-19 patients.
Sections du résumé
BACKGROUND
BACKGROUND
A high prevalence of pulmonary embolism (PE) has been described during COVID-19. Our aim was to identify predictive factors of PE in non-ICU hospitalized COVID-19 patients.
METHODS
METHODS
Data and outcomes were collected upon admission during a French multicenter retrospective study, including patients hospitalized for COVID-19, with a CT pulmonary angiography (CTPA) performed in the emergency department for suspected PE. Predictive factors significantly associated with PE were identified through a multivariate regression model.
RESULTS
RESULTS
A total of 88 patients (median [IQR] age of 68 years [60-78]) were analyzed. Based on CTPA, 47 (53.4%) patients were diagnosed with PE, and 41 were not. D-dimer ≥3000 ng/mL (OR 8.2 [95% CI] 1.3-74.2, sensitivity (Se) 0.84, specificity (Sp) 0.78, P = .03), white blood count (WBC) ≥12.0 G/L (29.5 [2.3-1221.2], Se 0.47, Sp 0.92, P = .02), and ferritin ≥480 µg/L (17.0 [1.7-553.3], Se 0.96, Sp 0.44, P = .03) were independently associated with the PE diagnosis. The presence of the double criterion D-dimer ≥3000 ng/mL and WBC ≥12.0 G/L was greatly associated with PE (OR 21.4 [4.0-397.9], P = .004).
CONCLUSION
CONCLUSIONS
The white blood count, the D-dimer and ferritin levels could be used as an indication for CTPA to confirm PE on admission in non-ICU COVID-19 patients.
Identifiants
pubmed: 34288162
doi: 10.1111/ejh.13638
pmc: PMC8239942
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Ferritins
9007-73-2
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
190-201Investigateurs
Albertini Mathieu
(A)
Bouajila Sara
(B)
Britany Kimbimbi
(B)
Burlacu Ruxandra
(B)
Cacoub Léa
(C)
Champion Karine
(C)
Delcey Véronique
(D)
Dillinger Jean-Guillaume
(D)
Feron Florine
(F)
Frazier Aline
(F)
Thomas Funck-Bretano
(T)
Gauthier Diane-Cecile
(G)
Gautier Jean-François
(G)
Henry Patrick
(H)
Huscenot Tessa
(H)
Sarah Izabel
(S)
Mathilde Jaulerry
(M)
Jouabli Moenes
(J)
Julla Jean-Baptiste
(J)
Laloi Michelin Marie
(LM)
Leroy Pierre
(L)
Lopes Amanda
(L)
Megarbane Bruno
(M)
Michon Maxime
(M)
Munier Anne-Lise
(M)
Nahmani Yoram
(N)
Nicol Martin
(N)
Nicolas Eroan
(N)
Poulat Audrey
(P)
Revue Eric
(R)
Richette Pascal
(R)
Riveline Jean-Pierre
(R)
Rubenstein Emma
(R)
Zanin Adrien
(Z)
Aveneau Clément
(A)
Bastard Paul
(B)
Beauvais Diane
(B)
Boghez Loredana
(B)
Borderiou Alix
(B)
Conway Paul
(C)
Cosma Lavignia
(C)
Davy Vincent
(D)
Desjardin Clément
(D)
Devatine Sandra
(D)
Ducroz Gerardin Christel
(DG)
Dupe Charlotte
(D)
Gobert Chloé
(G)
Gros Clotilde
(G)
Kadiri Soumaya
(K)
Khan Enmat
(K)
Ongnessek Sandrine
(O)
Rhmari Fatima
(R)
Sacco Isabelle
(S)
Saptefrat Natalia
(S)
Schaupp Pauline
(S)
Serre Justine
(S)
Sideris Georgios
(S)
Smati Sonia
(S)
Tournier Marine
(T)
Treca Pauline
(T)
Truong Tony
(T)
Tuffier Mathilde
(T)
Arcelli Mattéo
(A)
Boue Yvonnick
(B)
Copie Alban
(C)
Deye Nicolas
(D)
Ekherian Jean-Michel
(E)
Errabih Zaccaria
(E)
Gonde Antoine
(G)
Grant Caroline
(G)
Guerin Emmanuelle
(G)
Magalhaes Adèle
(M)
Malissin Isabelle
(M)
Meurisse Edouard
(M)
Mrad Aymen
(M)
Naim Giulia
(N)
Nguyen Philippe
(N)
Nitenberg Kiyoko
(N)
Pepin-Lehalleur Adrien
(PL)
Perault Arthur
(P)
Perrin Lucile
(P)
Renaud Maxime
(R)
Sutterlin Laetitia
(S)
Delrue Maxime
(D)
Siguret Virginie
(S)
Stepanian Alain
(S)
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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