Epidemiologic distinctions between base of tongue and tonsil oropharyngeal carcinomas.
NCDB
NHANES
head and neck cancer
human papillomavirus
oropharyngeal squamous cell carcinoma
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
13
05
2021
received:
26
12
2020
accepted:
28
06
2021
pubmed:
22
7
2021
medline:
30
9
2021
entrez:
21
7
2021
Statut:
ppublish
Résumé
Human papillomavirus (HPV)-positive tonsil and base of tongue (BOT) cancers have been considered together. However, important differences may exist. Demographic and tumor characteristics, and survival, were compared by oropharyngeal cancer subsite from 2004 to 2016 in the National Cancer Database (NCDB). Trends in tonsillectomy from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were examined. HPV-positive BOT (N = 13 081) were older than HPV-positive tonsil patients (N = 16 874; mean 61.5 vs. 58.4 years, p < 0.001), and individuals 70+ years were significantly more likely to have BOT tumors compared with individuals <50 (adjusted odd ratio [aOR] = 2.9, 95% confidence interval = 2.6-3.2). BOT patients were also more likely to be white, male, and have advanced tumor classification. Among 7418 NHANES participants, tonsillectomy was associated with older age and white race. There are epidemiologic and tumor-related differences among HPV-positive tonsil and BOT carcinomas. Demographic differences may be attributable to tonsillectomy trends.
Sections du résumé
BACKGROUND
Human papillomavirus (HPV)-positive tonsil and base of tongue (BOT) cancers have been considered together. However, important differences may exist.
METHODS
Demographic and tumor characteristics, and survival, were compared by oropharyngeal cancer subsite from 2004 to 2016 in the National Cancer Database (NCDB). Trends in tonsillectomy from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were examined.
RESULTS
HPV-positive BOT (N = 13 081) were older than HPV-positive tonsil patients (N = 16 874; mean 61.5 vs. 58.4 years, p < 0.001), and individuals 70+ years were significantly more likely to have BOT tumors compared with individuals <50 (adjusted odd ratio [aOR] = 2.9, 95% confidence interval = 2.6-3.2). BOT patients were also more likely to be white, male, and have advanced tumor classification. Among 7418 NHANES participants, tonsillectomy was associated with older age and white race.
CONCLUSIONS
There are epidemiologic and tumor-related differences among HPV-positive tonsil and BOT carcinomas. Demographic differences may be attributable to tonsillectomy trends.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3076-3085Subventions
Organisme : NIDCD NIH HHS
ID : T32 DC000027
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Van Dyne E, Jenley JS, Saraiya M, Thomas CC, Markowitz LE, Benard VB. Trends in human papillomavirus-associated cancers - United States, 1999-2015. MMWR Morb Mortal Wkly Rep. 2018;67(33):918-924.
Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100(4):261-269.
Bigelow EO, Seiwert TY, Fakhry C. Deintensification of treatment for human papillomavirus-related oropharyngeal cancer: current state and future directions. Oral Oncol. 2020;105:104652.
Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363:24-35.
Haeggblom L, Ramqvist T, Tommasino M, Dalianis T, Nasman A. Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years. Papillomavirus Res. 2017;4:1-11.
Kato MG, Ellis MA, Nguyen SA, Day TA. Predictors of contralateral-bilateral nodal disease in oropharyngeal cancer: a National Cancer Data Base Study. Head Neck. 2018;40(2):338-348.
Spector ME, Chinn SB, Bellile E, et al. Exploration for an algorithm for deintensification to exclude the retropharyngeal site from advanced oropharyngeal squamous cell carcinoma treatment. JAMA Otolaryngol Head Neck Surg. 2016;142(4):313-318.
Liederbach E, Lewis CM, Yao K, et al. A contemporary analysis of surgical trends in the treatment of squamous cell carcinoma of the oropharynx from 1998 to 2012: a report from the National Cancer Database. Ann Surg Oncol. 2015;22(13):4422-4431.
Edge S, Byrd D, Compton C, Fritz A, Greene F, Trotti A. AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010.
Amin M, Edge S, Greene F. AJCC Cancer Staging Manual. 8th ed.; New York: Springer; 2017.
NHANES 2011-2012, 2013-2014. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey Data Web Site. https://wwwn.cdc.gov/nchs/nhanes/Default.aspx. Accessed May 1, 2020.
Derkay C. Pediatric otolaryngology procedures in the United States: 1977-1987. Int J Pediatr Otorhinolaryngol. 1993;25(1-3):1-12.
Rosenfeld R, Green R. Tonsillectomy and adenoidectomy: changing trends. Ann Otol Rhinol Laryngol. 1990;99:187-191.
Fakhry C, Andersen KK, Eisele DW, Gillison ML. Oropharyngeal cancer survivorship in Denmark, 1977-2012. Oral Oncol. 2015;51:982-984.
Zevallos JP, Mazul AL, Rodriguez N, et al. Previous tonsillectomy modifies odds of tonsil and base of tongue cancer. Br J Cancer. 2016;114(7):832-838.
Altenhofen B, DeWees TA, Ahn JW, et al. Childhood tonsillectomy alters the primary distribution of HPV-related oropharyngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 2020;5(2):210-216.
Chiego DJ. Essentials of Oral Histology and Embryology. 4th ed. St. Louis, MO: Mosby; 2014.
Fossum CC, Chintakuntlawar AV, Price DL, Garcia JJ. Characterization of the oropharynx: anatomy, histology, immunology, squamous cell carcinoma and surgical resection. Histopathology. 2017;70(7):1021-1029.
Liu C, Mann D, Sinha UK, Kokot NC. The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review. J Otolaryngol Head Neck Surg. 2018;47(1):59.