Altered Adiponectin Response in Older Women Following Dextrose and High-Fat Dietary Challenges.
FGF21
adiponectin
inflammation
oxidative stress
postprandial
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
02
07
2021
received:
20
05
2021
pubmed:
22
7
2021
medline:
2
2
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Despite its beneficial properties, higher adiponectin concentrations are paradoxically associated with mortality in advanced age. Several mechanisms are being discussed. However, little is known about postprandial regulation of adiponectin in older adults. We assessed age-specific differences of the adiponectin response to different test meals considering potential determinants. Older (n = 20) and younger (n = 22) women are randomized to a dextrose (DEX) or high-fat (HF) dietary challenge. Postprandial adiponectin and fibroblast growth factor 21 (FGF21) concentrations are measured before and 60, 120, 240 min after ingestion. We assessed postprandial changes and group differences using linear mixed models controlled for possible determinants. In younger women, postprandial adiponectin remains stable after both test meals. In contrast, adiponectin increases following DEX and decreases after HF in older women, irrespective of control variables. Postprandial adiponectin is positively associated with malondialdehyde and inversely associated with interleukin-6 following DEX and also negatively associated with metabolic parameters after both test meals. In older women, elevated postprandial FGF21 concentrations are associated with a higher adiponectin response (β = 30.7, 95% CI 10.6-50.8, p = 0.007). Adiponectin response is associated with type of dietary challenge, age, and FGF21 response. Age-group differences are partly attributable to metabolic parameters and oxidative stress.
Identifiants
pubmed: 34288404
doi: 10.1002/mnfr.202100487
doi:
Substances chimiques
ADIPOQ protein, human
0
Adiponectin
0
Biomarkers
0
FGF21 protein, human
0
Fibroblast Growth Factors
62031-54-3
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100487Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
K. Robinson, J. Prins, B. Venkatesh, Crit. Care 2011, 15, 221.
T. Di Chiara, C. Argano, S. Corrao, R. Scaglione, G. Licata, J. Nutr. Metab. 2012, 2012, 175245.
C. Menzaghi, V. Trischitta, Diabetes 2018, 67, 12.
Y. Obata, Y. Yamada, Y. Takahi, M. Y. Baden, K. Saisho, S. Tamba, K. Yamamoto, M. Umeda, A. Furubayashi, Y. Matsuzawa, Clin. Endocrinol. (Oxf) 2013, 79, 204.
L. Woodward, I. Akoumianakis, C. Antoniades, Br. J. Pharmacol. 2017, 174, 4007.
G. Musso, R. Gambino, G. Pacini, F. De Michieli, M. Cassader, Am. J. Clin. Nutr. 2009, 89, 558.
L. K. Phillips, J. M. Peake, X. Zhang, I. J. Hickman, D. R. Briskey, B. E. Huang, P. Simpson, S. H. Li, J. P. Whitehead, J. H. Martin, J. B. Prins, Eur. J. Clin. Nutr. 2013, 67, 377.
P. J. English, S. R. Coughlin, K. Hayden, I. A. Malik, J. P. Wilding, Obes. Res. 2003, 11, 839.
M. A. Larsen, V. T. Isaksen, E. J. Paulssen, R. Goll, J. R. Florholmen, Endocrine 2019, 66, 517.
G. Musso, R. Gambino, M. Durazzo, G. Biroli, M. Carello, E. Faga, G. Pacini, F. De Michieli, L. Rabbione, A. Premoli, M. Cassader, G. Pagano, Hepatology 2005, 42, 1175.
S. Y. Lee, S. F. Burns, K. K. C. Ng, D. J. Stensel, L. Zhong, F. H. Y. Tan, K. L. Chia, K. D. Fam, M. M. C. Yap, K. P. Yeo, E. P. H. Yap, C. L. Lim, Med. Sci. Sports Exerc. 2020, 52, 370.
S. J. Chen, C. H. Yen, Y. C. Huang, B. J. Lee, S. Hsia, P. T. Lin, PLoS One 2012, 7, e45693.
G. Fruhbeck, V. Catalan, A. Rodriguez, B. Ramirez, S. Becerril, J. Salvador, P. Portincasa, I. Colina, J. Gomez-Ambrosi, Sci. Rep. 2017, 7, 6619.
S. Gustafsson, L. Lind, S. Soderberg, M. Zilmer, J. Hulthe, E. Ingelsson, Obesity (Silver Spring) 2013, 21, 1467.
T. Hajri, H. Tao, J. Wattacheril, P. Marks-Shulman, N. N. Abumrad, Am. J. Physiol. Endocrinol. Metab. 2011, 300, E350.
M. Matsuda, I. Shimomura, Horm. Mol. Biol. Clin. Investig. 2014, 19, 75.
W. L. Holland, A. C. Adams, J. T. Brozinick, H. H. Bui, Y. Miyauchi, C. M. Kusminski, S. M. Bauer, M. Wade, E. Singhal, C. C. Cheng, K. Volk, M. S. Kuo, R. Gordillo, A. Kharitonenkov, P. E. Scherer, Cell Metab. 2013, 17, 790.
G. Gaich, J. Y. Chien, H. Fu, L. C. Glass, M. A. Deeg, W. L. Holland, A. Kharitonenkov, T. Bumol, H. K. Schilske, D. E. Moller, Cell Metab. 2013, 18, 333.
C. Herpich, Haß U., Kochlik B., Franz K., Laeger T., Klaus S., Bosy-Westphal A., Norman K., Clin. Nutr. 2021, 40, 3765.
B. Schautz, W. Later, M. Heller, A. Peters, M. J. Muller, A. Bosy-Westphal, Br. J. Nutr. 2012, 108, 363.
U. G. Kyle, L. Genton, L. Karsegard, D. O. Slosman, C. Pichard, Nutrition 2001, 17, 248.
X. Hui, T. Feng, Q. Liu, Y. Gao, A. Xu, J. Mol. Cell Biol. 2016, 8, 110.
O. Tsukamoto, M. Fujita, M. Kato, S. Yamazaki, Y. Asano, A. Ogai, H. Okazaki, M. Asai, Y. Nagamachi, N. Maeda, Y. Shintani, T. Minamino, M. Asakura, I. Kishimoto, T. Funahashi, H. Tomoike, M. Kitakaze, J. Am. Coll. Cardiol. 2009, 53, 2070.
D. Weber, W. Stuetz, W. Bernhard, A. Franz, M. Raith, T. Grune, N. Breusing, Eur. J. Clin. Nutr. 2014, 68, 215.
S. H. Wong, J. A. Knight, S. M. Hopfer, O. Zaharia, C. N. Leach, Jr., F. W. Sunderman, Jr., Clin. Chem. 1987, 33, 214.
J. R. Dushay, E. Toschi, E. K. Mitten, F. M. Fisher, M. A. Herman, E. Maratos-Flier, Mol. Metab. 2015, 4, 51.
J. P. Araujo, P. Lourenco, F. Rocha-Goncalves, A. Ferreira, P. Bettencourt, Eur J Heart Fail 2009, 11, 567.
Y. Arai, K. Kamide, N. Hirose, Front Endocrinol (Lausanne) 2019, 10, 142.
M. Cnop, P. J. Havel, K. M. Utzschneider, D. B. Carr, M. K. Sinha, E. J. Boyko, B. M. Retzlaff, R. H. Knopp, J. D. Brunzell, S. E. Kahn, Diabetologia 2003, 46, 459.
D. Gradinaru, D. Margina, C. Borsa, C. Ionescu, M. Ilie, M. Costache, A. Dinischiotu, G. I. Prada, Aging Clin. Exp. Res. 2017, 29, 621.
L. M. Perez, H. Pareja-Galeano, F. Sanchis-Gomar, E. Emanuele, A. Lucia, B. G. Galvez, J. Physiol. 2016, 594, 3187.
D. B. Briggs, R. M. Giron, P. R. Malinowski, M. Nunez, T. S. Tsao, BMC Biochem. 2011, 12, 24.
H. Tang, B. M. Sebastian, A. Axhemi, X. Chen, A. D. Hillian, D. W. Jacobsen, L. E. Nagy, Alcohol Clin. Exp. Res. 2012, 36, 214.
S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, I. Shimomura, J. Clin. Invest. 2004, 114, 1752.
M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, J. Klein, R. Paschke, Biochem. Biophys. Res. Commun. 2003, 301, 1045.