Co-delivery of paclitaxel and STAT3 siRNA by a multifunctional nanocomplex for targeted treatment of metastatic breast cancer.
Antimetastasis
Chemo-gene therapy
Co-delivery and co-rapid release
Combinative antitumor efficacy
Multifunctional nanocomplex
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
28
02
2021
revised:
10
07
2021
accepted:
13
07
2021
pubmed:
22
7
2021
medline:
29
10
2021
entrez:
21
7
2021
Statut:
ppublish
Résumé
Metastasis is one of the major causes of mortality in patients suffering from breast cancer. The signal transducer and activator of transcription 3 (STAT3) is closely related to cancer metastasis. Herein, a multifunctional nanocomplex was developed to simultaneously deliver paclitaxel (PTX) and STAT3 siRNA (siSTAT3) to inhibit tumor growth and prevent metastasis of breast cancer cells. PTX was encapsulated into the synthesized polyethyleneimine-polylactic acid-lipoic acid (PPL) micelle through hydrophobic interaction, while siSTAT3 was condensed onto polyethyleneimine through electrostatic interaction. The surface charge of the drug-loaded nanocomplex (
Identifiants
pubmed: 34289420
pii: S1742-7061(21)00467-0
doi: 10.1016/j.actbio.2021.07.029
pii:
doi:
Substances chimiques
RNA, Small Interfering
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Hyaluronic Acid
9004-61-9
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
649-663Informations de copyright
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.