Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment.
Biomarkers
Rehabilitation
SNAP-25
Sarcopenia
miRNAs
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
21 07 2021
21 07 2021
Historique:
received:
08
04
2021
accepted:
14
07
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential for the maintenance of NMJ integrity, and the expression of this protein was shown to be modulated by the SNAP-25 rs363050 polymorphism and by a number of miRNAs. We analysed these parameters in a cohort of sarcopenic patients undergoing structured rehabilitation. The rs363050 genotype frequency distribution was analyzed in 177 sarcopenic patients and 181 healthy controls (HC). The concentration of seven miRNAs (miR-451a, miR-425-5p, miR155-5p, miR-421-3p, miR-495-3p, miR-744-5p and miR-93-5p), identified by mouse brain miRNome analysis to be differentially expressed in wild type compared to SNAP-25 The SNAP-25 rs363050 AA genotype was significantly more common in sarcopenic patients compared to HC (p These results support the hypothesis of a role for SNAP-25 in sarcopenia and suggest SNAP-25-associated miRNAs as circulatory biomarkers of rehabilitative outcome for sarcopenia.
Sections du résumé
BACKGROUND
Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential for the maintenance of NMJ integrity, and the expression of this protein was shown to be modulated by the SNAP-25 rs363050 polymorphism and by a number of miRNAs.
METHODS
We analysed these parameters in a cohort of sarcopenic patients undergoing structured rehabilitation. The rs363050 genotype frequency distribution was analyzed in 177 sarcopenic patients and 181 healthy controls (HC). The concentration of seven miRNAs (miR-451a, miR-425-5p, miR155-5p, miR-421-3p, miR-495-3p, miR-744-5p and miR-93-5p), identified by mouse brain miRNome analysis to be differentially expressed in wild type compared to SNAP-25
RESULTS
The SNAP-25 rs363050 AA genotype was significantly more common in sarcopenic patients compared to HC (p
CONCLUSION
These results support the hypothesis of a role for SNAP-25 in sarcopenia and suggest SNAP-25-associated miRNAs as circulatory biomarkers of rehabilitative outcome for sarcopenia.
Identifiants
pubmed: 34289870
doi: 10.1186/s12967-021-02989-x
pii: 10.1186/s12967-021-02989-x
pmc: PMC8296538
doi:
Substances chimiques
Biomarkers
0
MIRN495 microRNA, human
0
MicroRNAs
0
SNAP25 protein, human
0
Snap25 protein, mouse
0
Synaptosomal-Associated Protein 25
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
315Informations de copyright
© 2021. The Author(s).
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