High carbohydrate intakes may predict more inflammatory status than high fat intakes in pre-menopause women with overweight or obesity: a cross-sectional study.
Dietary carbohydrate
Dietary fat
Inflammation
Obesity
Pre-menopause
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
08
03
2021
accepted:
14
07
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
The associations between dietary carbohydrate, fat intake, and inflammation are controversial. Most existing data are from industrialized societies which low-carbohydrate and high-fat diet is common and so their attribution to other populations remains unclear. We evaluated the association of fat and carbohydrate intakes with inflammatory markers in pre-menopause women with overweight or obesity in Iran. Three hundred and sixty women with body mass index (BMI) ≥ 25 were included to this study. The levels of monocyte chemoattractant protein-1 (MCP-1) indicated a trend towards significance across tertiles of total dietary carbohydrate. We found that the levels of galectin-3 were negatively associated with dietary carbohydrate in adjusted model. In addition, the levels of MCP-1 and transforming growth factor beta (TGF-β) were positively correlated to dietary carbohydrate. No significant relationship was demonstrated between inflammatory parameters and total fat intake). However, there was a borderline significant negative association between total fat intake and TGF-β level in adjusted model. Therefore, a total dietary carbohydrate were related to elevated inflammation risk, while a total fat intake were not associated to higher inflammation. This study suggests reconsideration of applying global dietary guidelines in societies with high carbohydrate diet.
Identifiants
pubmed: 34289902
doi: 10.1186/s13104-021-05699-1
pii: 10.1186/s13104-021-05699-1
pmc: PMC8296741
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Fats
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
279Subventions
Organisme : Tehran University of Medical Sciences and Health Services
ID : 95-03-161-33142
Organisme : Tehran University of Medical Sciences and Health Services
ID : 97-03-161-41017
Organisme : Tehran University of Medical Sciences and Health Services
ID : 97-03-161-41144
Informations de copyright
© 2021. The Author(s).
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