The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
21 07 2021
Historique:
received: 15 01 2021
accepted: 02 07 2021
entrez: 22 7 2021
pubmed: 23 7 2021
medline: 7 8 2021
Statut: ppublish

Résumé

The emergence and spread of

Identifiants

pubmed: 34290058
pii: 13/603/eabg6013
doi: 10.1126/scitranslmed.abg6013
pmc: PMC8530196
mid: NIHMS1747318
pii:
doi:

Substances chimiques

Antimalarials 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
ID : 200909/Z/16/Z
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : T32 ES007020
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI139179
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124678
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109023
Pays : United States

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

James M Murithi (JM)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Cécile Pascal (C)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Jade Bath (J)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Xavier Boulenc (X)

Sanofi Pasteur, Marcy L'Etoile, France.

Nina F Gnädig (NF)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Charisse Flerida A Pasaje (CFA)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Kelly Rubiano (K)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Tomas Yeo (T)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Sachel Mok (S)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Sylvie Klieber (S)

Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.

Paul Desert (P)

Sanofi Pasteur, Marcy L'Etoile, France.

María Belén Jiménez-Díaz (MB)

The Art of Discovery, Bizkaia, Basque Country, Spain.

Jutta Marfurt (J)

Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.

Mélanie Rouillier (M)

Medicines for Malaria Venture, Geneva, Switzerland.

Mohammed H Cherkaoui-Rbati (MH)

Medicines for Malaria Venture, Geneva, Switzerland.

Nathalie Gobeau (N)

Medicines for Malaria Venture, Geneva, Switzerland.

Sergio Wittlin (S)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Universität Basel, Basel, Switzerland.

Anne-Catrin Uhlemann (AC)

Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Ric N Price (RN)

Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Grennady Wirjanata (G)

Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.

Rintis Noviyanti (R)

Eijkman Institute for Molecular Biology, Jakarta, Indonesia.

Patrick Tumwebaze (P)

Infectious Diseases Research Collaboration, Kampala, Uganda.

Roland A Cooper (RA)

Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA.

Philip J Rosenthal (PJ)

Department of Medicine, University of California, San Francisco, CA, USA.

Laura M Sanz (LM)

Global Health Pharma Research Unit, GSK, Tres Cantos, Madrid, Spain.

Francisco Javier Gamo (FJ)

Global Health Pharma Research Unit, GSK, Tres Cantos, Madrid, Spain.

Jayan Joseph (J)

Syngene International Ltd., Bangalore, India.

Shivendra Singh (S)

Syngene International Ltd., Bangalore, India.

Sridevi Bashyam (S)

Syngene International Ltd., Bangalore, India.

Jean Michel Augereau (JM)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Elie Giraud (E)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Tanguy Bozec (T)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Thierry Vermat (T)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Gilles Tuffal (G)

Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.

Jean-Michel Guillon (JM)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Jérôme Menegotto (J)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Laurent Sallé (L)

Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.

Guillaume Louit (G)

Sanofi, Vitry-sur-Seine, France.

Marie-José Cabanis (MJ)

Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.

Michel Doubovetzky (M)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Rita Merino (R)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Nadir Bessila (N)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Iñigo Angulo-Barturen (I)

The Art of Discovery, Bizkaia, Basque Country, Spain.

Delphine Baud (D)

Medicines for Malaria Venture, Geneva, Switzerland.

Lidiya Bebrevska (L)

Medicines for Malaria Venture, Geneva, Switzerland.

Fanny Escudié (F)

Medicines for Malaria Venture, Geneva, Switzerland.

Jacquin C Niles (JC)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Benjamin Blasco (B)

Medicines for Malaria Venture, Geneva, Switzerland.

Simon Campbell (S)

Medicines for Malaria Venture, Geneva, Switzerland.

Laurent Fraisse (L)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

Alain Pellet (A)

Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.

David A Fidock (DA)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2260@cumc.columbia.edu leroyd@mmv.org.
Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Didier Leroy (D)

Medicines for Malaria Venture, Geneva, Switzerland. df2260@cumc.columbia.edu leroyd@mmv.org.

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Classifications MeSH