The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 07 2021
21 07 2021
Historique:
received:
29
12
2020
accepted:
25
06
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
25
11
2021
Statut:
epublish
Résumé
While human papillomavirus is the primary cause of cervical cancer, other factors may influence susceptibility and response to the virus. Candidates include douching and talcum powder applied in the genital area. We used Cox proportional hazards models to estimate confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) in the Sister Study (2003-2009), a US cohort of women aged 35-74. We considered pre-baseline (n = 523) and incident (n = 31) cervical cancers. Douching at ages 10-13 was positively associated with pre-baseline cervical cancer (HR 1.32, 95% CI 0.86-2.03), though the association was not statistically significant. We did not observe an association between adolescent talc use and pre-baseline cervical cancer (HR 0.95, 95% CI 0.76-1.19). Douching in the year before enrollment was positively associated with incident cervical cancer (HR 2.56, 95% CI 1.10-5.99). The association between recent genital talc use and incident cervical cancer was positive, but not statistically significant (HR 1.79, 95% CI 0.78-4.11). The observed positive association between douching and incident cervical cancer is consistent with previous retrospective case-control studies. In the first study to examine genital talc use and cervical cancer, we did not see evidence of an association.
Identifiants
pubmed: 34290340
doi: 10.1038/s41598-021-94447-3
pii: 10.1038/s41598-021-94447-3
pmc: PMC8295379
doi:
Substances chimiques
Talc
14807-96-6
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14836Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : Intramural research, National Institute of Environmental Health Sciences
ID : Z01-ES044005
Organisme : Intramural NIH HHS
ID : ZIA ES102245
Pays : United States
Informations de copyright
© 2021. The Author(s).
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