Brain vulnerability and viability after ischaemia.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
accepted:
14
06
2021
pubmed:
23
7
2021
medline:
28
9
2021
entrez:
22
7
2021
Statut:
ppublish
Résumé
The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into question the temporal limits within which the brain is capable of tolerating prolonged circulatory arrest. This Review assesses cell type-specific mechanisms of global cerebral ischaemia, and examines the circumstances in which the brain exhibits heightened resilience to injury. We suggest strategies for expanding such discoveries to fuel translational research into novel cytoprotective therapies, and describe emerging technologies and experimental concepts. By doing so, we propose a new multimodal framework to investigate brain resuscitation following extended periods of circulatory arrest.
Identifiants
pubmed: 34290397
doi: 10.1038/s41583-021-00488-y
pii: 10.1038/s41583-021-00488-y
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
553-572Informations de copyright
© 2021. Springer Nature Limited.
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