An Autonomous Cannabinoid System in Islets of Langerhans.
cannabinoid receptors
diabetes
endocannabinoids
islet of Langerhans
obesity
β-cells
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
04
2021
accepted:
08
06
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
12
2
2022
Statut:
epublish
Résumé
While endocannabinoids (ECs) and cannabis were primarily studied for their nervous system effects, it is now clear that ECs are also produced in the periphery where they regulate several physiological processes, including energy storage, glucose and lipid metabolism, insulin secretion and synthesis, and hepatocyte function. Within islet of Langerhans there is an autonomous EC system (ECS). Beta (β)-cells contain all the enzymes necessary for EC synthesis and degradation; ECs are generated in response to cellular depolarization; their paracrine influence on β-cells is mostly through the cannabinoid 1 receptor (CB
Identifiants
pubmed: 34290671
doi: 10.3389/fendo.2021.699661
pmc: PMC8287299
doi:
Substances chimiques
Endocannabinoids
0
Receptors, Cannabinoid
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699661Informations de copyright
Copyright © 2021 Aseer and Egan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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